Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 2/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 4/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27730491 | 0.90 | LPAR1 (0.40) | LPAR1LPAR5TRPV1LPAR2C5AR1 | |
| SCHEMBL3581905 | 0.88 | NLRP3 (0.40) | SLC2A1LPAR1LPAR5LPAR2C5AR1 | |
| SCHEMBL3577794 | 0.87 | LMNA (0.37) | SLC2A1LPAR1LPAR5LMNAHPGD | |
| SCHEMBL3581173 | 0.85 | CCR1 (0.37) | SLC2A1LPAR1LPAR2LMNAHPGD | |
| SCHEMBL3577894 | 0.85 | TRPV1 (0.40) | SLC2A1SERPINE1LPAR1LPAR5TRPV1 | |
| SCHEMBL3576630 | 0.85 | LPAR1 (0.37) | LPAR1LPAR5LPAR2C5AR1ATM | |
| SCHEMBL3575570 | 0.84 | TRPV1 (0.42) | SLC2A1SERPINE1LPAR1LPAR5TRPV1 | |
| SCHEMBL3576381 | 0.83 | STAT3 (0.38) | LPAR1LPAR5LPAR2ATMCNR1 | |
| SCHEMBL3581285 | 0.83 | LPAR1 (0.36) | LPAR1LPAR5LPAR2C5AR1ATM | |
| SCHEMBL3581190 | 0.82 | TRPV1 (0.41) | SLC2A1SERPINE1LPAR1LPAR5TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |