Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TLR2 | O60603 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | GRB2 | P62993 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3632514 | 0.82 | EPHX2 (0.41) | EPHX2KMT2AALDH1A1MDM2MDM4 | |
| SCHEMBL3581504 | 0.79 | EPHX2 (0.58) | EPHX2KMT2AALDH1A1CASP3HTT | |
| SCHEMBL3571470 | 0.74 | EPHX2 (0.42) | EPHX2KMT2AALDH1A1MDM2HTT | |
| SCHEMBL3571474 | 0.74 | EPHX2 (0.42) | EPHX2KMT2AALDH1A1MDM2HTT | |
| SCHEMBL3579531 | 0.72 | EPHX2 (0.43) | EPHX2KMT2AALDH1A1MDM2MDM4 | |
| SCHEMBL3579026 | 0.72 | EPHX2 (0.43) | EPHX2KMT2AALDH1A1MDM2MDM4 | |
| SCHEMBL6389372 | 0.68 | KMT2A (0.55) | EPHX2KMT2AMDM4TP53CASP3 | |
| SCHEMBL16030101 | 0.67 | KMT2A (0.56) | EPHX2KMT2AMDM4TP53CASP3 | |
| SCHEMBL29221411 | 0.67 | KMT2A (0.56) | EPHX2KMT2AMDM4TP53CASP3 | |
| SCHEMBL16378096 | 0.67 | KMT2A (0.58) | EPHX2KMT2AMDM4TP53CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150514-B1 | 18F-LABELLED FOLATES | Merck & Cie (CH) | 2018-10-24 | — | — | EP | disclosed |
| US-9771368-B2 | 18F-labelled folates | Merck & Cie (CH) | 2017-09-26 | — | — | US | disclosed |
| US-20160159802-A1 | 18F-LABELLED FOLATES | Merck & Cie (CH) | 2016-06-09 | — | — | US | disclosed |
| US-9315506-B2 | 18F-labelled folates | Merck & Cie (CH) | 2016-04-19 | — | — | US | disclosed |
| US-20100056533-A1 | 18F-LABELLED FOLATES | MERCK EPROVA AG (CH) | 2010-03-04 | — | — | US | disclosed |
| EP-2150514-A2 | 18F-LABELLED FOLATES | Merck Eprova AG (CH) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008125617-A2 | 18F-LABELLED FOLATES | MERCK EPROVA AG (CH) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056533-A1 | 18F-LABELLED FOLATES | FOLR1, FOLR2, SLC19A1 | EPHX2 2090/4885KMT2A 1304/4885ALDH1A1 1012/4885 |
| US-20160159802-A1 | 18F-LABELLED FOLATES | FOLR1, FOLR2, SLC19A1 | EPHX2 2012/4885KMT2A 1210/4885ALDH1A1 942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.