Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TLR2 | O60603 | 2/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579026 | 1.00 | EPHX2 (0.43) | EPHX2MDM2ALDH1A1KMT2APTPN1 | |
| SCHEMBL27791396 | 0.87 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL3577196 | 0.87 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL3569098 | 0.87 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL3633589 | 0.83 | ITGA4 (0.30) | — | |
| SCHEMBL3571474 | 0.81 | EPHX2 (0.42) | EPHX2MDM2ALDH1A1KMT2A | |
| SCHEMBL3571470 | 0.81 | EPHX2 (0.42) | EPHX2MDM2ALDH1A1KMT2A | |
| SCHEMBL3574028 | 0.79 | ALDH1A1 (0.40) | ALDH1A1KMT2A | |
| SCHEMBL3632510 | 0.78 | TYMS (0.32) | MDM2TNFTLR2 | |
| SCHEMBL3574966 | 0.77 | ITGA4 (0.35) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150514-B1 | 18F-LABELLED FOLATES | Merck & Cie (CH) | 2018-10-24 | — | — | EP | disclosed |
| US-9771368-B2 | 18F-labelled folates | Merck & Cie (CH) | 2017-09-26 | — | — | US | disclosed |
| US-20160159802-A1 | 18F-LABELLED FOLATES | Merck & Cie (CH) | 2016-06-09 | — | — | US | disclosed |
| US-9315506-B2 | 18F-labelled folates | Merck & Cie (CH) | 2016-04-19 | — | — | US | disclosed |
| US-20100056533-A1 | 18F-LABELLED FOLATES | MERCK EPROVA AG (CH) | 2010-03-04 | — | — | US | disclosed |
| EP-2150514-A2 | 18F-LABELLED FOLATES | Merck Eprova AG (CH) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008125617-A2 | 18F-LABELLED FOLATES | MERCK EPROVA AG (CH) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056533-A1 | 18F-LABELLED FOLATES | FOLR1, FOLR2, SLC19A1 | EPHX2 2090/4885MDM2 3194/4885ALDH1A1 1012/4885 |
| US-20160159802-A1 | 18F-LABELLED FOLATES | FOLR1, FOLR2, SLC19A1 | EPHX2 2012/4885MDM2 3456/4885ALDH1A1 942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.