Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13932577 | 0.87 | KDM4E (0.65) | HPGDHTTALDH1A1GAAL3MBTL1 | |
| SCHEMBL3575043 | 0.83 | EPHX2 (0.57) | MAPK14HPGDALDH1A1MT-CO2KDM4E | |
| SCHEMBL3579623 | 0.81 | HPGD (0.68) | MAPK14HPGDHTTALDH1A1MAPK8 | |
| SCHEMBL3583284 | 0.78 | MAPK14 (0.54) | MAPK14HPGDALDH1A1APEX1MT-CO2 | |
| SCHEMBL5709300 | 0.78 | HPGD (0.84) | MAPK14HPGDHTTALDH1A1LMNA | |
| SCHEMBL920461 | 0.78 | MAPK8 (0.67) | MAPK14HPGDHTTALDH1A1MAPK8 | |
| SCHEMBL15953971 | 0.77 | LIPG (0.80) | MAPK14HPGDHTTALDH1A1MAPK8 | |
| SCHEMBL16749017 | 0.77 | MAPK8 (0.62) | MAPK14HPGDHTTALDH1A1MAPK8 | |
| SCHEMBL923999 | 0.77 | MAPK14 (0.52) | MAPK14HPGDHTTALDH1A1MAPK8 | |
| SCHEMBL3576438 | 0.76 | KDM4E (0.49) | MAPK14HPGDHTTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-20070219261-A1 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219261-A1 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | AADAT, AAAS, AADAC | MAPK14 2731/4885HPGD 1361/4885HTT 2128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.