SCHEMBL920461

SCHEMBL920461

Nc1ncccc1C(=O)NCc1ccc(Oc2ccccc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 1/20 0.67
MAPK14 Q16539 3/20 0.56
HTT P42858 2/20 0.56
LMNA P02545 2/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
CYP3A4 P08684 1/20 0.56
MMP13 P45452 1/20 0.56
HPGD P15428 3/20 0.54
ALDH1A1 P00352 2/20 0.54
GAA P10253 1/20 0.54
ATM Q13315 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
NSD2 O96028 1/20 0.53
MEN1 O00255 1/20 0.53
MAPT P10636 1/20 0.53
KMT2A Q03164 1/20 0.53
PRKCI P41743 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL920569 0.91 MAPK8 (0.56) MAPK8MAPK14HTTLMNASMN1; SMN2
SCHEMBL920221 0.90 MAPK8 (0.55) MAPK8MAPK14HTTLMNASMN1; SMN2
SCHEMBL920343 0.90 KMT2A (0.61) MAPK8MAPK14LMNASMN1; SMN2CYP3A4
SCHEMBL922484 0.90 HPGD (0.62) MAPK8MAPK14HTTLMNASMN1; SMN2
SCHEMBL921037 0.90 HPGD (0.66) MAPK8LMNASMN1; SMN2HPGDALDH1A1
SCHEMBL920473 0.90 HPGD (0.57) MAPK8LMNASMN1; SMN2HPGDALDH1A1
SCHEMBL920265 0.90 MAPK8 (0.55) MAPK8MAPK14HTTLMNASMN1; SMN2
SCHEMBL922025 0.90 ALDH1A1 (0.58) MAPK8MAPK14HTTLMNASMN1; SMN2
SCHEMBL921604 0.90 MAPK8 (0.55) MAPK8LMNASMN1; SMN2HPGDALDH1A1
SCHEMBL920793 0.89 LMNA (0.61) MAPK8LMNASMN1; SMN2HPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9161538-B2 Pyridine compound and agricultural fungicide NIPPON SODA CO., LTD. (JP) 2015-10-20 US disclosed
US-9161538-B2 Pyridine compound and agricultural fungicide NIPPON SODA CO., LTD. (JP) 2015-10-20 US disclosed
US-20150189878-A1 PYRIDINE COMPOUND AND AGRICULTURAL FUNGICIDE NIPPON SODA CO., LTD. (JP) 2015-07-09 US disclosed
US-20150189878-A1 PYRIDINE COMPOUND AND AGRICULTURAL FUNGICIDE NIPPON SODA CO., LTD. (JP) 2015-07-09 US disclosed
EP-2876106-A1 PYRIDINE COMPOUND AND AGRICULTURAL FUNGICIDE Nippon Soda Co., Ltd. (JP) 2015-05-27 EP disclosed
CN-101951771-A Composition for agricultural use for controlling or preventing plant diseases caused by plant pathogens SUMITOMO CHEMICAL CO 2011-01-19 CN disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed
WO-2009107764-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS 住友化学株式会社 (JP) 2009-09-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 MAPK8 2313/4885MAPK14 905/4885HTT 2561/4885
US-20150189878-A1 PYRIDINE COMPOUND AND AGRICULTURAL FUNGICIDE PNPO, CYP4X1, CYP4F12 MAPK8 3369/4885MAPK14 2081/4885HTT 2078/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.