Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | GRK5 | P34947 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27730389 | 0.92 | S1PR1 (0.37) | S1PR1GRK5CDK8S1PR5PGR | |
| SCHEMBL3586256 | 0.89 | STAT3 (0.35) | KCNH2STAT3 | |
| SCHEMBL3580976 | 0.87 | MCL1 (0.35) | S1PR1GRK5CDK8S1PR5PGR | |
| SCHEMBL27730380 | 0.87 | LMNA (0.34) | S1PR1GRK5CDK8S1PR5PGR | |
| SCHEMBL3577794 | 0.87 | LMNA (0.37) | S1PR1GRK5CDK8S1PR5KCNH2 | |
| SCHEMBL3578656 | 0.84 | MCL1 (0.37) | S1PR1GRK5CDK8S1PR5SLC2A1 | |
| SCHEMBL3581173 | 0.84 | CCR1 (0.37) | S1PR1GRK5CDK8S1PR5KCNH2 | |
| SCHEMBL3579273 | 0.83 | LMNA (0.37) | S1PR1GRK5CDK8S1PR5MEN1 | |
| SCHEMBL27730387 | 0.82 | S1PR1 (0.36) | S1PR1GRK5CDK8S1PR5PGR | |
| SCHEMBL27730488 | 0.81 | SLC6A9 (0.35) | KCNH2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |