Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | GRK5 | P34947 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 5/20 | 0.33 |
| ▸ | UBE2M | P61081 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27730387 | 0.92 | S1PR1 (0.36) | MCL1LMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL3578656 | 0.91 | MCL1 (0.37) | MCL1LMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL3586258 | 0.89 | CNR1 (0.34) | DCUN1D1UBE2M | |
| SCHEMBL3579273 | 0.88 | LMNA (0.37) | MCL1LMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL27730378 | 0.87 | LMNA (0.35) | MCL1LMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL3580975 | 0.87 | S1PR1 (0.34) | MCL1LMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL3577795 | 0.87 | LMNA (0.38) | LMNAMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3583574 | 0.86 | HSD11B1 (0.34) | LMNAMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27750941 | 0.85 | MCL1 (0.37) | MCL1LMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL3581174 | 0.84 | LMNA (0.37) | LMNAMEN1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |