Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LSS | P48449 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.39 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.37 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3583612 | 0.94 | KDM4E (0.40) | C5AR1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3583688 | 0.90 | C5AR1 (0.42) | C5AR1LSSSERPINE1MBTPS1LPAR1 | |
| SCHEMBL3583345 | 0.89 | C5AR1 (0.40) | C5AR1ALDH1A1LSSSERPINE1MBTPS1 | |
| SCHEMBL3576623 | 0.87 | LMNA (0.41) | C5AR1CCR1MEN1HPGDKMT2A | |
| SCHEMBL3583320 | 0.85 | CNR1 (0.41) | C5AR1LPAR1LPAR5KDM4C | |
| SCHEMBL3583638 | 0.84 | C5AR1 (0.41) | C5AR1LSSMBTPS1MAPTMCHR1 | |
| SCHEMBL3584209 | 0.84 | C5AR1 (0.45) | C5AR1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3576432 | 0.84 | C5AR1 (0.43) | C5AR1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3569717 | 0.83 | LMNA (0.40) | C5AR1CCR1MEN1HPGDKMT2A | |
| SCHEMBL3584396 | 0.83 | C5AR1 (0.44) | C5AR1KDM4EALDH1A1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |