Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.37 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 4/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576351 | 0.88 | MCHR1 (0.35) | C5AR1MCHR1MAPTOPRM1OPRD1 | |
| SCHEMBL3576804 | 0.88 | SIGMAR1 (0.36) | MCHR1MAPTFFAR4OPRM1OPRD1 | |
| SCHEMBL3573226 | 0.86 | CNR1 (0.37) | MEN1KMT2A | |
| SCHEMBL3577569 | 0.85 | C5AR1 (0.42) | C5AR1F10CHRNA7KLKB1MEN1 | |
| SCHEMBL3581049 | 0.84 | C5AR1 (0.43) | C5AR1MCHR1LSSMBTPS1MAPT | |
| SCHEMBL3574398 | 0.83 | STAT3 (0.37) | MEN1KMT2A | |
| SCHEMBL3569329 | 0.83 | C5AR1 (0.41) | C5AR1F10CHRNA7KLKB1MEN1 | |
| SCHEMBL3581889 | 0.82 | C5AR1 (0.40) | C5AR1F10CHRNA7KLKB1MEN1 | |
| SCHEMBL3576589 | 0.82 | CHRNA7 (0.40) | C5AR1MAPTF10CHRNA7MEN1 | |
| SCHEMBL3578672 | 0.80 | GBA1 (0.34) | MAPTOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |