Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 2/20 | 0.59 |
| ▸ | KDM1A | O60341 | 7/20 | 0.56 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3587812 | 0.96 | KLKB1 (0.59) | KLKB1KDM1AADAMTS5L3MBTL1ADAMTS4 | |
| SCHEMBL3584887 | 0.92 | KLKB1 (0.69) | KLKB1KDM1AADAMTS5L3MBTL1ADAMTS4 | |
| SCHEMBL3588585 | 0.89 | KLKB1 (0.57) | KLKB1KDM1AADAMTS5ADAMTS4NFKB1 | |
| SCHEMBL3576509 | 0.87 | ADAMTS5 (0.62) | KLKB1KDM1AADAMTS5L3MBTL1ADAMTS4 | |
| SCHEMBL2251666 | 0.86 | NPC1 (0.67) | KLKB1ADAMTS5ADAMTS4NPC1RAB9A | |
| SCHEMBL3586210 | 0.86 | ADAMTS5 (0.58) | KLKB1KDM1AADAMTS5L3MBTL1ADAMTS4 | |
| SCHEMBL3577147 | 0.85 | KLKB1 (0.56) | KLKB1KDM1AADAMTS5ADAMTS4NPC1 | |
| SCHEMBL2246982 | 0.85 | KLKB1 (0.54) | KLKB1KDM1AADAMTS5L3MBTL1ADAMTS4 | |
| SCHEMBL2244081 | 0.85 | ADAMTS5 (0.54) | KLKB1KDM1AADAMTS5ADAMTS4NPC1 | |
| SCHEMBL3589769 | 0.85 | KLKB1 (0.62) | KLKB1KDM1AADAMTS5L3MBTL1ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | claimed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | claimed |
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2010-01-14 | — | — | US | disclosed |
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | ADAMTS5, ADAMTS1, ADAMTS7 | KLKB1 1174/4885KDM1A 634/4885ADAMTS5 1/4885 |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | KLKB1 1174/4885KDM1A 634/4885ADAMTS5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.