Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 9/20 | 0.38 |
| ▸ | VDR | P11473 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 7/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA3 | P07451 | 2/20 | 0.37 |
| ▸ | CA4 | P22748 | 2/20 | 0.37 |
| ▸ | CA6 | P23280 | 2/20 | 0.37 |
| ▸ | CA5A | P35218 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15574179 | 0.94 | THRA (0.40) | NPC1CYP3A4THRAVDRTHRB | |
| SCHEMBL15574355 | 0.91 | ALDH1A1 (0.40) | NPC1CYP3A4THRAVDRTHRB | |
| SCHEMBL15573232 | 0.91 | SMN1; SMN2 (0.41) | NPC1CYP3A4THRAVDRTHRB | |
| SCHEMBL15574831 | 0.90 | THRA (0.43) | NPC1CYP3A4THRAVDRTHRB | |
| SCHEMBL15572713 | 0.90 | NPC1 (0.38) | NPC1CYP3A4THRAVDRTHRB | |
| SCHEMBL18506059 | 0.89 | THRA (0.38) | NPC1CYP3A4THRAVDRTHRB | |
| SCHEMBL15574585 | 0.88 | NPC1 (0.40) | NPC1CYP3A4THRAVDRTHRB | |
| SCHEMBL15573697 | 0.88 | THRA (0.44) | NPC1CYP3A4THRAVDRTHRB | |
| SCHEMBL15573655 | 0.87 | NPC1 (0.39) | NPC1CYP3A4THRAVDRTHRB | |
| SCHEMBL17180950 | 0.87 | THRA (0.37) | NPC1CYP3A4THRAVDRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150299230-A1 | Novel Prodrugs And Methods Of Use Thereof | Convert Pharmaceuticals SA (BE) | 2015-10-22 | — | — | US | claimed |
| EP-2888227-A1 | NOVEL PRODRUGS AND METHODS OF USE THEREOF | Auckland Uniservices Limited (NZ) | 2015-07-01 | — | — | EP | claimed |
| WO-2014031012-A1 | NOVEL PRODRUGS AND METHODS OF USE THEREOF | AUCKLAND UNISERVICES LIMITED (NZ) | 2014-02-27 | — | — | WO | claimed |
| US-20100010094-A1 | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents | AUCKLAND UNISERVICES LIMITED (NZ) | 2010-01-14 | — | — | US | claimed |
| US-20070032455-A1 | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents | AUCKLAND UNIVERVICES LIMITED (NZ) | 2007-02-08 | — | — | US | claimed |
| EP-2888227-B1 | NOVEL PRODRUGS AND METHODS OF USE THEREOF | Convert Pharmaceuticals SA (BE) | 2020-07-29 | — | — | EP | disclosed |
| US-20190153002-A1 | Novel Prodrugs And Methods Of Use Thereof | Convert Pharmaceuticals SA (BE) | 2019-05-23 | — | — | US | disclosed |
| US-10202408-B2 | Prodrugs and methods of use thereof | HEALTH INNOVATION VENTURES B.V. (NL) | 2019-02-12 | — | — | US | disclosed |
| US-20180148463-A1 | Novel Prodrugs And Methods Of Use Thereof | Convert Pharmaceuticals SA (BE) | 2018-05-31 | — | — | US | disclosed |
| US-9873710-B2 | Prodrugs and methods of use thereof | HEALTH INNOVATION VENTURES B.V. (NL) | 2018-01-23 | — | — | US | disclosed |
| US-20170044191-A1 | Novel Prodrugs And Methods Of Use Thereof | Convert Pharmaceuticals SA (BE) | 2017-02-16 | — | — | US | disclosed |
| US-20170044191-A1 | Novel Prodrugs And Methods Of Use Thereof | Convert Pharmaceuticals SA (BE) | 2017-02-16 | — | — | US | disclosed |
| US-20100010094-A1 | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents | AUCKLAND UNISERVICES LIMITED (NZ) | 2010-01-14 | — | — | US | disclosed |
| US-7629332-B2 | Nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents | AUCKLAND UNISERVICES LIMITED (NZ) | 2009-12-08 | — | — | US | disclosed |
| US-7629332-B2 | Nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents | AUCKLAND UNISERVICES LIMITED (NZ) | 2009-12-08 | — | — | US | disclosed |
| US-20070032455-A1 | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents | AUCKLAND UNIVERVICES LIMITED (NZ) | 2007-02-08 | — | — | US | disclosed |
| US-20070032455-A1 | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents | AUCKLAND UNIVERVICES LIMITED (NZ) | 2007-02-08 | — | — | US | disclosed |
| EP-1680394-A4 | NOVEL NITROPHENYL MUSTARD AND NITROPHENYLAZIRIDINE ALCOHOLS AND THEIR CORRESPONDING PHOSPHATES AND THEIR USE AS TARGETED CYTOTOXIC AGENTS | AUCKLAND UNISERVICES LTD (NZ) | 2006-10-11 | — | — | EP | disclosed |
| EP-1680394-A1 | NOVEL NITROPHENYL MUSTARD AND NITROPHENYLAZIRIDINE ALCOHOLS AND THEIR CORRESPONDING PHOSPHATES AND THEIR USE AS TARGETED CYTOTOXIC AGENTS | Auckland Uniservices Limited (NZ) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005042471-A1 | NOVEL NITROPHENYL MUSTARD AND NITROPHENYLAZIRIDINE ALCOHOLS AND THEIR CORRESPONDING PHOSPHATES AND THEIR USE AS TARGETED CYTOTOXIC AGENTS | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148463-A1 | Novel Prodrugs And Methods Of Use Thereof | AKR1C3, AKR1C2, AKR1B1 | NPC1 998/4885CYP3A4 498/4885THRA 2653/4885 |
| US-20190153002-A1 | Novel Prodrugs And Methods Of Use Thereof | AKR1C3, AKR1C2, AKR1B1 | NPC1 998/4885CYP3A4 498/4885THRA 2653/4885 |
| US-20150299230-A1 | Novel Prodrugs And Methods Of Use Thereof | AKR1C3, AKR1C2, AKR1B1 | NPC1 998/4885CYP3A4 498/4885THRA 2653/4885 |
| US-20070032455-A1 | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents | NAPRT, NTPCR, PNP | NPC1 1359/4885CYP3A4 477/4885THRA 3130/4885 |
| US-10202408-B2 | Prodrugs and methods of use thereof | AKR1C3, AKR1C2, AKR1C1 | NPC1 1040/4885CYP3A4 227/4885THRA 2773/4885 |
| US-20100010094-A1 | Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents | NAPRT, NTPCR, QDPR | NPC1 1461/4885CYP3A4 588/4885THRA 3012/4885 |
| US-20170044191-A1 | Novel Prodrugs And Methods Of Use Thereof | AKR1C3, AKR1C2, AKR1B1 | NPC1 998/4885CYP3A4 498/4885THRA 2653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.