Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581360 | 0.93 | MCL1 (0.40) | MCL1LMNAHPGDHDAC8MEN1 | |
| SCHEMBL3576028 | 0.91 | MCL1 (0.39) | MCL1LMNAHPGDHDAC8MEN1 | |
| SCHEMBL27750941 | 0.88 | MCL1 (0.37) | MCL1LMNAHPGDHDAC8MEN1 | |
| SCHEMBL3589427 | 0.88 | MCL1 (0.38) | MCL1LMNAHPGDHDAC8MEN1 | |
| SCHEMBL3580675 | 0.87 | LMNA (0.40) | MCL1LMNAHPGDHDAC8MEN1 | |
| SCHEMBL3575609 | 0.85 | LMNA (0.43) | LMNAHPGDHDAC8MEN1CYP1A2 | |
| SCHEMBL3582291 | 0.84 | MCL1 (0.39) | MCL1LMNAHPGDHDAC8MEN1 | |
| SCHEMBL12520884 | 0.84 | TACR1 (0.40) | LMNAHPGDHDAC8MEN1CYP1A2 | |
| SCHEMBL3581012 | 0.84 | HDAC8 (0.37) | MCL1LMNAHDAC8MEN1CYP1A2 | |
| SCHEMBL3577275 | 0.84 | MCL1 (0.39) | MCL1LMNAHPGDHDAC8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |