Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580861 | 0.93 | MCL1 (0.38) | MCL1MEN1KMT2AHDAC8LMNA | |
| SCHEMBL3574614 | 0.91 | HDAC8 (0.39) | MCL1MEN1KMT2AHDAC8LMNA | |
| SCHEMBL3581012 | 0.89 | HDAC8 (0.37) | MCL1MEN1KMT2AHDAC8LMNA | |
| SCHEMBL3584856 | 0.88 | LMNA (0.39) | MCL1MEN1KMT2AHDAC8LMNA | |
| SCHEMBL3583628 | 0.88 | MCL1 (0.40) | MCL1MEN1KMT2AHDAC8LMNA | |
| SCHEMBL3576028 | 0.86 | MCL1 (0.39) | MCL1MEN1KMT2AHDAC8LMNA | |
| SCHEMBL12520884 | 0.86 | TACR1 (0.40) | MEN1KMT2AHDAC8LMNACYP1A2 | |
| SCHEMBL3576036 | 0.86 | HDAC8 (0.39) | MEN1KMT2AHDAC8HDAC1SLC2A1 | |
| SCHEMBL12521229 | 0.85 | SLC2A1 (0.43) | HDAC8HDAC1SLC2A1HDAC11HDAC6 | |
| SCHEMBL12521170 | 0.85 | OPRM1 (0.44) | MCL1MEN1KMT2AHDAC8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |