Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582883 | 0.90 | RAF1 (0.40) | RAF1MAP2K1HCRTR1HCRTR2OPRM1 | |
| SCHEMBL3576619 | 0.86 | SLC2A1 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL3573203 | 0.82 | RAF1 (0.40) | RAF1MAP2K1HCRTR1HCRTR2OPRM1 | |
| SCHEMBL12520972 | 0.80 | TRPM8 (0.37) | TRPM8LPAR1LPAR5OPRM1OPRD1 | |
| SCHEMBL3578408 | 0.78 | TRPV1 (0.40) | RAF1AURKARPS6KB1KDR | |
| SCHEMBL12520875 | 0.78 | TRPM8 (0.40) | TRPM8LPAR1LPAR5OPRM1OPRD1 | |
| SCHEMBL3580658 | 0.78 | RAF1 (0.39) | RAF1MAP2K1HCRTR1HCRTR2KDR | |
| SCHEMBL12521116 | 0.77 | TRPM8 (0.40) | TRPM8LPAR1LPAR5 | |
| SCHEMBL12521050 | 0.77 | TRPM8 (0.38) | RAF1KCNN4TRPM8LPAR1LPAR5 | |
| SCHEMBL12521179 | 0.76 | LPAR1 (0.44) | TRPM8LPAR1LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |