Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | ESRRG | P62508 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | ESRRB | O95718 | 1/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3583632 | 0.90 | RAF1 (0.37) | RAF1MAP2K1OPRM1OPRD1HCRTR1 | |
| SCHEMBL3573203 | 0.89 | RAF1 (0.40) | RAF1MAP2K1MAPTMEN1KMT2A | |
| SCHEMBL3580658 | 0.87 | RAF1 (0.39) | RAF1MAP2K1MEN1KMT2ACYP2C19 | |
| SCHEMBL3576619 | 0.85 | SLC2A1 (0.43) | MAPTMEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL3578664 | 0.85 | CYP2C19 (0.39) | MAPTMEN1KMT2ACYP2C19OPRM1 | |
| SCHEMBL3575452 | 0.84 | KMT2A (0.42) | RAF1MAP2K1NPC1RAB9AMEN1 | |
| SCHEMBL3581464 | 0.84 | TRPV1 (0.41) | RAF1MAP2K1MAPTMEN1KMT2A | |
| SCHEMBL3580336 | 0.84 | MAPT (0.42) | RAF1MAP2K1MAPTMEN1KMT2A | |
| SCHEMBL3581747 | 0.84 | CCR9 (0.39) | RAF1MAP2K1MAPTMEN1KMT2A | |
| SCHEMBL3576126 | 0.83 | CYP2C19 (0.37) | MAPTMEN1KMT2ACYP2C19OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |