Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5187771 | 0.91 | TRPM8 (0.45) | TRPM8EPHX1FFAR1FFAR2MME | |
| SCHEMBL3272260 | 0.89 | TRPM8 (0.45) | TRPM8EPHX1FFAR1 | |
| SCHEMBL3581268 | 0.84 | EPHX1 (0.48) | TRPM8EPHX1FFAR1MMEGPR139 | |
| SCHEMBL3581412 | 0.83 | EPHX1 (0.48) | TRPM8EPHX1PTPN1 | |
| SCHEMBL5177434 | 0.82 | EPHX1 (0.47) | TRPM8EPHX1FFAR1MME | |
| SCHEMBL5175895 | 0.81 | EPHX1 (0.50) | TRPM8EPHX1FFAR1 | |
| SCHEMBL3272981 | 0.78 | EPHX1 (0.45) | EPHX1ALDH1A1GAA | |
| SCHEMBL28107953 | 0.78 | EPHX1 (0.65) | TRPM8EPHX1FFAR1PTPN1 | |
| SCHEMBL5178678 | 0.75 | TRPM8 (0.40) | TRPM8EPHX1FFAR1GPR139 | |
| SCHEMBL5177355 | 0.75 | L3MBTL1 (0.49) | EPHX1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |