Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3573023 | 0.92 | LMNA (0.39) | HDAC8HDAC1HDAC6HDAC11LMNA | |
| SCHEMBL3586388 | 0.88 | ESRRG (0.38) | HDAC8HDAC6HDAC11C5AR1 | |
| SCHEMBL12521079 | 0.87 | LMNA (0.44) | HDAC8HDAC1HDAC6HDAC11LMNA | |
| SCHEMBL3580675 | 0.86 | LMNA (0.40) | HDAC8HDAC1HDAC6HDAC11LMNA | |
| SCHEMBL3575609 | 0.86 | LMNA (0.43) | HDAC8HDAC1HDAC6HDAC11LMNA | |
| SCHEMBL12521085 | 0.85 | HDAC8 (0.42) | HDAC8HDAC1HDAC6HDAC11LMNA | |
| SCHEMBL12521133 | 0.85 | LMNA (0.41) | HDAC8HDAC1HDAC6HDAC11LMNA | |
| SCHEMBL12521103 | 0.84 | LMNA (0.40) | HDAC8HDAC1HDAC6HDAC11LMNA | |
| SCHEMBL3570653 | 0.84 | CNR1 (0.39) | HDAC8HDAC1HDAC6HDAC11LMNA | |
| SCHEMBL12521286 | 0.84 | LMNA (0.51) | HDAC8HDAC1HDAC6HDAC11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |