Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 3/20 | 0.38 |
| ▸ | ESRRB | O95718 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | CENPE | Q02224 | 4/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584266 | 0.88 | HDAC8 (0.40) | HDAC8HDAC6C5AR1HDAC11 | |
| SCHEMBL3579634 | 0.84 | SERPINE1 (0.40) | ESRRGESRRBNR1H4HSP90AA1SIGMAR1 | |
| SCHEMBL3583634 | 0.82 | SERPINE1 (0.39) | ESRRGESRRBNR1H4HSP90AA1TP53 | |
| SCHEMBL3577419 | 0.81 | NR1H4 (0.37) | ESRRGESRRBNR1H4SIGMAR1TP53 | |
| SCHEMBL3576692 | 0.81 | ESRRG (0.37) | ESRRGESRRBNR1H4HSP90AA1SIGMAR1 | |
| SCHEMBL3575452 | 0.81 | KMT2A (0.42) | ESRRGESRRBNR1H4HSP90AA1SIGMAR1 | |
| SCHEMBL3570707 | 0.80 | C5AR1 (0.39) | ESRRGESRRBNR1H4HSP90AA1TP53 | |
| SCHEMBL3574285 | 0.80 | ESRRG (0.36) | ESRRGESRRBNR1H4HSP90AA1SIGMAR1 | |
| SCHEMBL12521166 | 0.80 | ESRRG (0.44) | ESRRGESRRBNR1H4SIGMAR1TP53 | |
| SCHEMBL12521072 | 0.80 | TP53 (0.39) | ESRRGESRRBNR1H4HSP90AA1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |