Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.59 |
| ▸ | DHODH | Q02127 | 1/20 | 0.56 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.53 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.53 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.53 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.53 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6579004 | 0.85 | PARP1 (0.41) | PARP1DHODHPKN2DYRK3MAP4K4 | |
| SCHEMBL3577208 | 0.84 | PARP1 (0.55) | PARP1DHODHPKN2DYRK3MAP4K4 | |
| SCHEMBL3584745 | 0.84 | PARP1 (0.39) | PARP1DHODHPKN2DYRK3MAP4K4 | |
| SCHEMBL7763628 | 0.83 | MGAM (0.53) | — | |
| SCHEMBL3580135 | 0.81 | AURKB (0.61) | PARP1DHODHPKN2DYRK3MAP4K4 | |
| SCHEMBL7135042 | 0.79 | PARP1 (0.82) | PARP1DHODHPKN2DYRK3MAP4K4 | |
| SCHEMBL3582857 | 0.76 | PARP1 (0.66) | PARP1DHODHPKN2DYRK3MAP4K4 | |
| SCHEMBL7139354 | 0.75 | PARP1 (0.83) | PARP1DHODHPKN2DYRK3MAP4K4 | |
| SCHEMBL3585138 | 0.75 | PARP1 (1.00) | PARP1DHODHPKN2DYRK3MAP4K4 | |
| SCHEMBL7765872 | 0.75 | MGAM (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |