Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584741 | 0.84 | PARP1 (0.59) | PARP1PIM1PIM3AURKBDYRK3 | |
| SCHEMBL3580139 | 0.81 | AURKB (0.46) | PARP1PIM1PIM3AURKBDHODH | |
| SCHEMBL3582864 | 0.76 | GRK6 (0.48) | PARP1CYP3A4CYP2C9 | |
| SCHEMBL3585144 | 0.75 | PARP1 (0.64) | PARP1PIM1AURKBMAP4K4HIPK2 | |
| SCHEMBL7136552 | 0.75 | PARP1 (0.52) | PARP1PIM1PIM3AURKBDHODH | |
| SCHEMBL3576439 | 0.75 | KDR (0.38) | PARP1AURKBPKN2DHODHCYP3A4 | |
| SCHEMBL3579908 | 0.75 | PARP1 (0.61) | PARP1PIM1PIM3AURKBDYRK3 | |
| SCHEMBL3580302 | 0.74 | DYRK3 (0.54) | PARP1PIM1PIM3AURKBDYRK3 | |
| SCHEMBL29696369 | 0.74 | NPC1 (0.53) | PARP1DHODHCYP3A4CYP2C9 | |
| SCHEMBL3575207 | 0.74 | DYRK3 (0.53) | PARP1PIM1PIM3AURKBDYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |