Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 8/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL3585426 | 0.90 | TNFRSF1A (0.38) | TNFRSF1AMAPTTSHRTPSAB1ALOX5AP | |
| SCHEMBL3591933 | 0.88 | MAPT (0.40) | MAPTALOX5APFEN1KDM4EALDH1A1 | |
| SCHEMBL3585207 | 0.88 | MAPT (0.40) | TNFRSF1AMAPTTSHRKDM4EALDH1A1 | |
| SCHEMBL3581931 | 0.86 | HPGDS (0.41) | TNFRSF1AMAPTTPSAB1ALOX5APFEN1 | |
| SCHEMBL3590068 | 0.81 | TNFRSF1A (0.36) | TNFRSF1AMAPTTSHRKDM4EALDH1A1 | |
| Tromethamine SCHEMBL3585206 | 0.76 | TNFRSF1A (0.40) | TNFRSF1AMAPTTSHRKDM4EALDH1A1 | |
| SCHEMBL3598526 | 0.74 | MAPT (0.42) | TNFRSF1AMAPTTSHRKDM4EALDH1A1 | |
| SCHEMBL3584180 | 0.72 | HPGDS (0.44) | TNFRSF1AMAPTTSHRKDM4EALDH1A1 | |
| SCHEMBL3586048 | 0.71 | TOP1 (0.48) | TNFRSF1AMAPTTSHRKDM4EALDH1A1 | |
| SCHEMBL14390864 | 0.71 | MAPT (0.38) | TNFRSF1AMAPTALOX5APFEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100009973-A1 | Integrase Inhibitors 3 | AVEXA LIMITED (AU) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009973-A1 | Integrase Inhibitors 3 | TYMP, IMPDH1, IMPDH2 | TNFRSF1A 3388/4885MAPT 3484/4885TSHR 4692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.