Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 10/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL3590066 | 0.89 | TNFRSF1A (0.39) | TNFRSF1AMAPTTSHRRETSIRT2 | |
| SCHEMBL3592169 | 0.88 | MAPT (0.40) | MAPTRETSIRT2HPGDSHPGD | |
| SCHEMBL3585765 | 0.86 | HPGDS (0.42) | TNFRSF1AMAPTRETSIRT2HPGDS | |
| SCHEMBL3585207 | 0.83 | MAPT (0.40) | TNFRSF1AMAPTTSHRPOLBHPGD | |
| SCHEMBL3585430 | 0.81 | TNFRSF1A (0.36) | TNFRSF1AMAPTTSHRHDAC1POLB | |
| SCHEMBL3586048 | 0.74 | TOP1 (0.48) | TNFRSF1AMAPTTSHRPOLBHPGD | |
| Tromethamine SCHEMBL3585206 | 0.72 | TNFRSF1A (0.40) | TNFRSF1AMAPTTSHRHPGDSHPGD | |
| Tromethamine SCHEMBL3585426 | 0.71 | TNFRSF1A (0.38) | TNFRSF1AMAPTTSHRHDAC1HPGDS | |
| SCHEMBL3598526 | 0.69 | MAPT (0.42) | TNFRSF1AMAPTTSHRHPGDKDM4E | |
| SCHEMBL3591933 | 0.68 | MAPT (0.40) | MAPTHDAC1HPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100009973-A1 | Integrase Inhibitors 3 | AVEXA LIMITED (AU) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009973-A1 | Integrase Inhibitors 3 | TYMP, IMPDH1, IMPDH2 | TNFRSF1A 3388/4885MAPT 3484/4885TSHR 4692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.