Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 12/20 | 0.60 |
| ▸ | NPC1 | O15118 | 11/20 | 0.60 |
| ▸ | MAPT | P10636 | 10/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 3/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28848905 | 0.95 | GRK6 (0.59) | GRK6RAB9ANPC1MAPTSMN1; SMN2 | |
| Boric Acid SCHEMBL28661630 | 0.94 | GRK6 (0.57) | GRK6RAB9ANPC1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28662000 | 0.94 | GRK6 (0.57) | GRK6RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL29236600 | 0.84 | GRK6 (0.66) | GRK6RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL993416 | 0.82 | GRK6 (0.64) | GRK6RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL11199551 | 0.80 | RAB9A (0.58) | GRK6RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL2245602 | 0.79 | GRK6 (0.69) | GRK6RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL24338807 | 0.79 | PIK3CD (0.43) | GRK6RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL13986779 | 0.79 | KDM4E (0.54) | RAB9ANPC1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL21104415 | 0.79 | MEN1 (0.62) | RAB9ANPC1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004222-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | RENOVIS, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| US-20100004222-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | RENOVIS, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| US-20100004222-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | RENOVIS, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| WO-2007100758-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004222-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | TRPV1, TRPA1, TRPV2 | GRK6 1195/4885RAB9A 2452/4885NPC1 879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.