Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1860307 | 0.95 | ALDH1A1 (0.60) | HRH3ALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL1856613 | 0.90 | KDM4E (0.57) | HRH3ALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL6824130 | 0.85 | ALDH1A1 (0.69) | ALDH1A1KDM4EPOLBHPGDALOX15 | |
| SCHEMBL1859145 | 0.85 | HRH3 (0.67) | HRH3HPGD | |
| SCHEMBL30109094 | 0.84 | HRH3 (0.69) | HRH3 | |
| SCHEMBL1742384 | 0.81 | ALDH1A1 (0.53) | HRH3ALDH1A1KDM4EPOLB | |
| SCHEMBL4467331 | 0.80 | HRH3 (0.69) | HRH3 | |
| SCHEMBL7535374 | 0.80 | HRH3 (0.55) | HRH3 | |
| Hydrochloric Acid SCHEMBL4003401 | 0.80 | ALDH1A1 (0.52) | HRH3ALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL1743019 | 0.80 | HPGD (0.55) | HRH3ALDH1A1KDM4EPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1972914-A | As histamine H3Non-imidazole heterocyclic compounds of receptor ligands | JANSSEN PHARMACEUTICA NV (BE) | 2007-05-30 | — | — | CN | claimed |
| US-20100022539-A1 | Isoxazole Compounds as Histamine H3 modulators | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-28 | — | — | US | disclosed |
| US-20080306066-A1 | NON-IMIDAZOLE HETEROCYCLIC COMPOUNDS | CARRUTHERS NICHOLAS I | 2008-12-11 | — | — | US | disclosed |
| US-7423147-B2 | Pyridine compounds as histamine H3 modulators | JANSSEN PHARMACEUTICAL, N.V. (BE) | 2008-09-09 | — | — | US | disclosed |
| CN-1972914-A | As histamine H3Non-imidazole heterocyclic compounds of receptor ligands | JANSSEN PHARMACEUTICA NV (BE) | 2007-05-30 | — | — | CN | disclosed |
| US-20050222151-A1 | Non-Imidazole heterocyclic compounds | JANSSEN PHARMACEUTICAL, N.V. (BE) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022539-A1 | Isoxazole Compounds as Histamine H3 modulators | HRH3, HRH4, HRH1 | HRH3 1/4885ALDH1A1 3279/4885KDM4E 893/4885 |
| US-20050222151-A1 | Non-Imidazole heterocyclic compounds | HRH3, HRH4, HRH2 | HRH3 1/4885ALDH1A1 2417/4885KDM4E 845/4885 |
| US-20080306066-A1 | NON-IMIDAZOLE HETEROCYCLIC COMPOUNDS | HRH3, HRH4, HRH2 | HRH3 1/4885ALDH1A1 2417/4885KDM4E 845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.