Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13031308 | 0.91 | CYP19A1 (0.58) | CYP19A1KDM4EMAPTALDH1A1POLB | |
| Trifluoroacetic Acid SCHEMBL3583791 | 0.83 | KDM4E (0.39) | CYP19A1KDM4EMAPTALDH1A1POLB | |
| SCHEMBL26919578 | 0.78 | CYP19A1 (0.47) | CYP19A1KDM4EMAPTALDH1A1POLB | |
| Trifluoroacetic Acid SCHEMBL16700571 | 0.76 | ALDH1A1 (0.44) | CYP19A1KDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL25404336 | 0.76 | CYP19A1 (0.43) | CYP19A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL25401555 | 0.75 | CYP19A1 (0.49) | CYP19A1KDM4EMAPTALDH1A1LMNA | |
| SCHEMBL3591115 | 0.73 | CYP19A1 (0.45) | CYP19A1KDM4EMAPTALDH1A1LMNA | |
| SCHEMBL6855316 | 0.73 | CYP19A1 (0.47) | CYP19A1KDM4EMAPTALDH1A1LMNA | |
| SCHEMBL4453709 | 0.72 | ALDH1A1 (0.46) | CYP19A1KDM4EMAPTALDH1A1POLB | |
| Trifluoroacetic Acid SCHEMBL3586206 | 0.72 | KDM4E (0.37) | KDM4EMAPTALDH1A1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | MERCK SHARP & DOHME CORP. | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286191-A1 | 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators | CXCR3, CXCR1, CXCR2 | CYP19A1 3384/4885KDM4E 3447/4885MAPT 4292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.