Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 14/20 | 0.46 |
| ▸ | CTSL | P07711 | 11/20 | 0.44 |
| ▸ | CTSK | P43235 | 8/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | LDHB | P07195 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3595483 | 0.78 | CTSS (0.69) | CTSSCTSLCTSK | |
| SCHEMBL3586215 | 0.73 | CTSS (0.51) | CTSSCTSLCTSK | |
| SCHEMBL3587059 | 0.72 | CTSS (0.41) | CTSSCTSLCTSK | |
| SCHEMBL3596145 | 0.70 | CTSS (0.52) | CTSSCTSLCTSK | |
| SCHEMBL3587062 | 0.70 | CTSS (0.55) | CTSSCTSLCTSK | |
| SCHEMBL3587063 | 0.68 | CTSS (0.57) | CTSSCTSLCTSK | |
| SCHEMBL5791335 | 0.68 | CTSS (0.58) | CTSSCTSLCTSK | |
| SCHEMBL3591329 | 0.68 | SYK (0.35) | — | |
| SCHEMBL3586488 | 0.67 | CTSS (0.68) | CTSSCTSLCTSK | |
| SCHEMBL5571991 | 0.65 | CTSS (0.59) | CTSSCTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704996-B2 | Compounds and compositions useful as cathepsin S inhibitors | NOVARTIS AG (CH) | 2010-04-27 | — | — | US | disclosed |
| US-20090048230-A1 | COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS | NOVARTIS AG (CH) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048230-A1 | COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS | CTSS, CTSZ, CTSF | CTSS 1/4885CTSL 9/4885CTSK 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.