SCHEMBL358811

SCHEMBL358811

NNc1ccccc1C(F)(F)F

nearest known ligand 0.95

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 4/20 0.95
ALDH1A1 P00352 2/20 0.95
TDP1 Q9NUW8 2/20 0.95
L3MBTL1 Q9Y468 1/20 0.95
GRIN2D O15399 1/20 0.49
GRIN3B O60391 1/20 0.49
GRIN1 Q05586 1/20 0.49
GRIN2A Q12879 1/20 0.49
GRIN2B Q13224 1/20 0.49
GRIN2C Q14957 1/20 0.49
GRIN3A Q8TCU5 1/20 0.49
SIGMAR1 Q99720 1/20 0.49
IDO1 P14902 2/20 0.45
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
KDM4E B2RXH2 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
GAA P10253 3/20 0.42
EPHX2 P34913 1/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29573158 1.00 POLB (0.95) POLBALDH1A1TDP1L3MBTL1GRIN2D
Hydrochloric Acid SCHEMBL31013084 0.98 POLB (1.00) POLBALDH1A1TDP1L3MBTL1GRIN2D
Bromide SCHEMBL20984100 0.98 POLB (0.91) POLBALDH1A1TDP1L3MBTL1GRIN2D
Hydrochloric Acid SCHEMBL1408149 0.98 POLB (1.00) POLBALDH1A1TDP1L3MBTL1GRIN2D
Methyl Alcohol SCHEMBL28589868 0.94 ALDH1A1 (0.84) POLBALDH1A1TDP1L3MBTL1GRIN2D
Phosphoric Acid SCHEMBL20984218 0.88 POLB (0.75) POLBALDH1A1TDP1L3MBTL1GRIN2D
Oxalic Acid SCHEMBL20984131 0.88 POLB (0.75) POLBALDH1A1TDP1L3MBTL1MEN1
Sulfuric Acid SCHEMBL20984884 0.88 POLB (0.75) POLBALDH1A1TDP1L3MBTL1GRIN2D
Nitric Acid SCHEMBL20984720 0.85 POLB (0.70) POLBALDH1A1TDP1L3MBTL1GRIN2D
SCHEMBL2746683 0.83 ALDH1A1 (0.68) POLBALDH1A1TDP1L3MBTL1GRIN2D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 313 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113024385-B Preparation method of 2,2 '-bis (trifluoromethyl) -4, 4' -diaminobiphenyl 西安瑞联新材料股份有限公司 2022-08-16 CN claimed
CN-113024385-A Preparation method of 2,2 '-bis (trifluoromethyl) -4, 4' -diaminobiphenyl 西安瑞联新材料股份有限公司 2021-06-25 CN claimed
EP-3174852-B1 ARYLHYDRAZIDES CONTAINING A 2-PYRIDONE MOIETY AS SELECTIVE ANTIBACTERIAL AGENTS ABAC THERAPEUTICS S L (ES) 2018-07-18 EP claimed
CN-106660962-A Arylhydrazides containing 2-pyridone moieties for use as selective antibacterial agents ABAC治疗法有限公司 2017-05-10 CN claimed
CN-101525294-B Method for preparing 2,2'-bis(trifluoromethyl)-4,4'-diaminodiphenyl CHANGZHOU SUNLIGHT PHARM CO LTD 2013-02-27 CN claimed
CN-101102992-B Process for producing 2,2'-bis(trifluoromethyl)-4,4'-diaminobiphenyl AIR WATER CHEMICAL INC 2011-06-29 CN claimed
CN-101525294-A Method for preparing 2,2'-bis(trifluoromethyl)-4,4'-diaminodiphenyl CHANGZHOU SUNLIGHT MEDICAL RAW 2009-09-09 CN claimed
CN-101102992-A Process for producing 2,2'-bis(trifluoromethyl)-4,4'-diaminobiphenyl AIR WATER CHEMICAL INC (JP) 2008-01-09 CN claimed
US-4531963-A Promoting germination of oil seeds THE UPJOHN COMPANY (US) 1985-07-30 US claimed
CN-118852082-A Flavonol derivative containing hydrazide active fragment and application thereof 南京农业大学 2024-10-29 CN disclosed
CN-115124430-B Synthesis process of 2,2' -di (trifluoromethyl) diaminobiphenyl 苏利制药科技江阴有限公司 2024-05-07 CN disclosed
CN-111278821-B Spiro compounds as farnesol X receptor modulators 百时美施贵宝公司 2023-10-03 CN disclosed
WO-2023089074-A1 AUTOPHAGY INDUCING COMPOUNDS AND USES THEREOF, IN PARTICULAR FOR A SYSTEMIC TREATMENT OF DISEASES AND CONDITIONS Samsara Therapeutics Inc. (US) 2023-05-25 WO disclosed
EP-4183449-A1 AUTOPHAGY INDUCING COMPOUNDS AND USES THEREOF Samsara Therapeutics Inc. (US) 2023-05-24 EP disclosed
US-4411839-A α-Cyano-β-(trisubstituted phenylhydrazino)-n-ethoxycarbonylacrylamides ZOECON CORPORATION (US) 1983-10-25 US disclosed
US-4359474-A ANTIDIABETIC AGENTS SANDOZ, INC. (US) 1982-11-16 US disclosed
US-4008217-A HERBICIDE THE UPJOHN COMPANY (US) 1977-02-15 US disclosed
US-4005076-A ANTIBIOTICS GRUPPO LEPETIT S.P.A. (IT) 1977-01-25 US disclosed
US-3979412-A Process for producing 3-anilino-5-pyrazolones FUJI PHOTO FILM CO., LTD. (JA) 1976-09-07 US disclosed
US-3933874-A Method for preparing of β-anilino-β-hydrazinoacrylates FUJI PHOTO FILM CO., LTD. (JA) 1976-01-20 US disclosed