Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL358811 | 0.83 | POLB (0.95) | ALDH1A1TDP1POLBL3MBTL1GRIN2D | |
| SCHEMBL29573158 | 0.83 | POLB (0.95) | ALDH1A1TDP1POLBL3MBTL1GRIN2D | |
| Hydrochloric Acid SCHEMBL31013084 | 0.81 | POLB (1.00) | ALDH1A1TDP1POLBL3MBTL1GRIN2D | |
| Bromide SCHEMBL20984100 | 0.81 | POLB (0.91) | ALDH1A1TDP1POLBL3MBTL1GRIN2D | |
| Hydrochloric Acid SCHEMBL1408149 | 0.81 | POLB (1.00) | ALDH1A1TDP1POLBL3MBTL1GRIN2D | |
| Methyl Alcohol SCHEMBL28589868 | 0.78 | ALDH1A1 (0.84) | ALDH1A1TDP1POLBL3MBTL1GRIN2D | |
| Phosphoric Acid SCHEMBL20984218 | 0.73 | POLB (0.75) | ALDH1A1TDP1POLBL3MBTL1GRIN2D | |
| Sulfuric Acid SCHEMBL20984884 | 0.73 | POLB (0.75) | ALDH1A1TDP1POLBL3MBTL1GRIN2D | |
| Oxalic Acid SCHEMBL20984131 | 0.73 | POLB (0.75) | ALDH1A1TDP1POLBL3MBTL1SMN1; SMN2 | |
| Nitric Acid SCHEMBL20984720 | 0.71 | POLB (0.70) | ALDH1A1TDP1POLBL3MBTL1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732904-B1 | DIARYLTRIAZOLES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2014-03-19 | — | — | EP | disclosed |
| US-8178546-B2 | Diaryltriazoles as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | MERCK SHARP & DOHME CORP. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100256387-A1 | DIARYLTRIAZOLES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2010-10-07 | — | — | US | disclosed |
| US-20080255216-A1 | Diaryltriazoles as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | MERCK SHARP & DOHME CORP. | 2008-10-16 | — | — | US | disclosed |
| EP-1732904-A4 | DIARYLTRIAZOLES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK & CO INC (US) | 2007-11-14 | — | — | EP | disclosed |
| EP-1732904-A1 | DIARYLTRIAZOLES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | Merck & Co., Inc. (US) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005097759-A1 | DIARYLTRIAZOLES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK & CO., INC. (US) | 2005-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256387-A1 | DIARYLTRIAZOLES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | HSD11B1, HSD11B2, HSD3B1 | ALDH1A1 189/4885TDP1 678/4885POLB 2617/4885 |
| US-20080255216-A1 | Diaryltriazoles as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | HSD11B1, HSD11B2, HSD17B1 | ALDH1A1 320/4885TDP1 702/4885POLB 2743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.