Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 2/20 | 0.38 |
| ▸ | PRKCA | P17252 | 2/20 | 0.38 |
| ▸ | PRKCH | P24723 | 2/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989779 | 0.92 | CYP4F2 (0.40) | CYP4F2CYP4A11PRKCBPRKCAPRKCH | |
| Dimethylamine SCHEMBL5206984 | 0.88 | KDM4E (0.39) | CYP4F2CYP4A11PRKCBPRKCAPRKCH | |
| SCHEMBL3596009 | 0.84 | AKR1B1 (0.42) | NCEH1PRKCBPRKCAPRKCHPRKCE | |
| SCHEMBL3588222 | 0.83 | SLC6A4 (0.46) | NCEH1PRKCBPRKCAPRKCHPRKCE | |
| SCHEMBL3586690 | 0.81 | KDM4E (0.42) | KDM4ELMNAL3MBTL1MAPTHTT | |
| SCHEMBL3591326 | 0.79 | PTGS2 (0.50) | KDM4ELMNAL3MBTL1MAPTHTT | |
| SCHEMBL3591481 | 0.79 | KDM4E (0.40) | KDM4ELMNAL3MBTL1MAPTHTT | |
| SCHEMBL27664986 | 0.79 | RAD52 (0.43) | CYP4F2CYP4A11NCEH1PRKCBPRKCA | |
| SCHEMBL3588920 | 0.77 | NCEH1 (0.46) | NCEH1KDM4ELMNAL3MBTL1MAPT | |
| SCHEMBL857027 | 0.75 | KDM4E (0.47) | KDM4ELMNAMAPTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7691861-B2 | Indolymaleimide derivatives | NOVARTIS AG (CH) | 2010-04-06 | — | — | US | disclosed |
| US-20080234494-A1 | Indolylmaleimide Derivatives | NOVARTIS AG (CH) | 2008-09-25 | — | — | US | disclosed |
| EP-1709030-B1 | INDOLYLMALEIMIDE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| EP-1709030-A1 | INDOLYLMALEIMIDE DERIVATIVES | Novartis AG (CH) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005068454-A1 | INDOLYLMALEIMIDE DERIVATIVES | NOVARTIS AG (CH) | 2005-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234494-A1 | Indolylmaleimide Derivatives | IDH3A, INMT, IDH2 | CYP4F2 1971/4885CYP4A11 1603/4885NCEH1 1392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.