Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.42 |
| ▸ | PRKCB | P05771 | 2/20 | 0.41 |
| ▸ | PRKCA | P17252 | 2/20 | 0.41 |
| ▸ | PRKCH | P24723 | 2/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR1E | P28566 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3588222 | 0.88 | SLC6A4 (0.46) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL3588780 | 0.84 | CYP4F2 (0.40) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL27664986 | 0.79 | RAD52 (0.43) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL992003 | 0.78 | SLC6A4 (0.46) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL989779 | 0.74 | CYP4F2 (0.40) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| Dimethylamine SCHEMBL5206984 | 0.72 | KDM4E (0.39) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL3594857 | 0.71 | KDM4E (0.67) | AKR1B1KDM4EALDH1A1GLAGAA | |
| SCHEMBL27664987 | 0.71 | PRKCB (0.38) | PRKCBPRKCAPRKCHPRKCEPRKCQ | |
| SCHEMBL27626651 | 0.70 | ALDH1A1 (0.52) | HTR2AHTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL11747172 | 0.69 | AKR1B1 (0.50) | AKR1B1CA2SLC22A12PTGS1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1910174-B | Indolylmaleimide derivatives | NOVARTIS AG | 2010-06-09 | — | — | CN | disclosed |
| US-7691861-B2 | Indolymaleimide derivatives | NOVARTIS AG (CH) | 2010-04-06 | — | — | US | disclosed |
| US-20080234494-A1 | Indolylmaleimide Derivatives | NOVARTIS AG (CH) | 2008-09-25 | — | — | US | disclosed |
| EP-1709030-B1 | INDOLYLMALEIMIDE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| CN-1910174-A | Indolylmaleimide derivatives | NOVARTIS AG (CH) | 2007-02-07 | — | — | CN | disclosed |
| EP-1709030-A1 | INDOLYLMALEIMIDE DERIVATIVES | Novartis AG (CH) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005068454-A1 | INDOLYLMALEIMIDE DERIVATIVES | NOVARTIS AG (CH) | 2005-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234494-A1 | Indolylmaleimide Derivatives | IDH3A, INMT, IDH2 | AKR1B1 147/4885PRKCB 3670/4885PRKCA 3950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.