Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.46 |
| ▸ | GABRP | O00591 | 6/20 | 0.46 |
| ▸ | GABRD | O14764 | 6/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.46 |
| ▸ | GABRE | P78334 | 6/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.46 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16584905 | 0.85 | MAPK1 (0.54) | POLBGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL10003611 | 0.84 | CYP1A2 (0.53) | POLBGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL22912573 | 0.82 | POLB (0.51) | POLBGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL12359014 | 0.82 | POLB (0.51) | POLBGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1645417 | 0.81 | CYP1A2 (0.50) | POLBGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL127058 | 0.80 | POLB (0.49) | POLBGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL31172634 | 0.80 | CYP4F2 (0.50) | POLBGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL14288423 | 0.80 | POLB (0.49) | POLBGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL480097 | 0.80 | POLB (0.53) | POLBGABRA1GABRG2GABRB3GABRA5 | |
| Alcohol SCHEMBL11011386 | 0.80 | POLB (0.49) | POLBGABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085572-B2 | 4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-07-21 | — | — | US | disclosed |
| US-9085572-B2 | 4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-07-21 | — | — | US | disclosed |
| US-9085572-B2 | 4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-07-21 | — | — | US | disclosed |
| US-20120322772-A1 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-12-20 | — | — | US | disclosed |
| US-20120322772-A1 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-12-20 | — | — | US | disclosed |
| US-20120322772-A1 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-12-20 | — | — | US | disclosed |
| US-8252817-B2 | Dipyridyl-dihydropyrazolones and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-08-28 | — | — | US | disclosed |
| US-8252817-B2 | Dipyridyl-dihydropyrazolones and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-08-28 | — | — | US | disclosed |
| US-8252817-B2 | Dipyridyl-dihydropyrazolones and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-08-28 | — | — | US | disclosed |
| US-20100035906-A1 | Dipyridyl-dihydropyrazolones and their use | BAYER HEALTHCARE AG (DE) | 2010-02-11 | — | — | US | disclosed |
| US-20100035906-A1 | Dipyridyl-dihydropyrazolones and their use | BAYER HEALTHCARE AG (DE) | 2010-02-11 | — | — | US | disclosed |
| US-20100035906-A1 | Dipyridyl-dihydropyrazolones and their use | BAYER HEALTHCARE AG (DE) | 2010-02-11 | — | — | US | disclosed |
| EP-1877396-B1 | 4-(PYRIDIN-3-YL)-2-(PYRIDIN-2-YL)-1,2-DIHYDRO-3H-PYRAZOL-3-ONE DERIVATIVES AS SPECIFIC HIF-PROLYL-4-HYDROXYLASE INHIBITORS FOR TREATING CARDIOVASCULAR AND HAEMATOLOGICAL DISEASES | BAYER HEALTHCARE AG (DE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2006114213-A1 | 4-(PYRIDIN-3-YL)-2-(PYRIDIN-2-YL)-1,2-DIHYDRO-3H-PYRAZOL-3-ONE DERIVATIVES AS SPECIFIC HIF-PROLYL-4-HYDROXYLASE INHIBITORS FOR TREATING CARDIOVASCULAR AND HAEMATOLOGICAL DISEASES | BAYER HEALTHCARE AG (DE) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322772-A1 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | PPIP5K2, THPO, DPYD | POLB 1191/4885GABRA1 4382/4885GABRG2 4373/4885 |
| US-20100035906-A1 | Dipyridyl-dihydropyrazolones and their use | DPP7, DPP4, QDPR | POLB 1175/4885GABRA1 4378/4885GABRG2 4500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.