Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263098 | 0.81 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1LMNAGAAALOX15 | |
| SCHEMBL223413 | 0.81 | GAA (0.49) | ALDH1A1L3MBTL1LMNAGAAALOX15 | |
| Hydrochloric Acid SCHEMBL19119186 | 0.79 | GAA (0.47) | ALDH1A1L3MBTL1LMNAGAAALOX15 | |
| SCHEMBL3643406 | 0.79 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1LMNAGAAALOX15 | |
| SCHEMBL193631 | 0.79 | LMNA (0.50) | ALDH1A1L3MBTL1LMNAGAAALOX15 | |
| SCHEMBL352276 | 0.79 | GAA (0.53) | ALDH1A1L3MBTL1LMNAGAAALOX15 | |
| Hydrochloric Acid SCHEMBL5009791 | 0.77 | GAA (0.51) | ALDH1A1L3MBTL1LMNAGAAALOX15 | |
| SCHEMBL27554843 | 0.77 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1LMNABRD4GAA | |
| SCHEMBL2176508 | 0.77 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1LMNAGAAALOX15 | |
| SCHEMBL14790745 | 0.77 | ALDH1A1 (0.37) | ALDH1A1L3MBTL1LMNABRD4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109001-A1 | GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2022-05-27 | — | — | WO | disclosed |
| EP-2935256-B1 | 4,6-DIARYLAMINOTHIAZINES AS BACE1 INHIBITORS AND THEIR USE FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL MYERS SQUIBB CO (US) | 2018-01-24 | — | — | EP | disclosed |
| WO-2016202898-A1 | GLUCOSE TRANSPORT INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-12-22 | — | — | WO | disclosed |
| US-9475784-B2 | 4,6-diarylaminothiazines as BACE1 inhibitors and their use for the reduction of beta-amyloid production | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-10-25 | — | — | US | disclosed |
| US-9475784-B2 | 4,6-diarylaminothiazines as BACE1 inhibitors and their use for the reduction of beta-amyloid production | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-10-25 | — | — | US | disclosed |
| US-9321790-B2 | Pyrimidinone derivatives as antimalarial agents | SANOFI (FR) | 2016-04-26 | — | — | US | disclosed |
| US-9321790-B2 | Pyrimidinone derivatives as antimalarial agents | SANOFI (FR) | 2016-04-26 | — | — | US | disclosed |
| WO-2016012333-A1 | PESTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2016-01-28 | — | — | WO | disclosed |
| US-20150368213-A1 | Novel Inhibitors of System Xc- | THE UNIVERSITY OF MONTANA | 2015-12-24 | — | — | US | disclosed |
| US-20150329506-A1 | 4,6-DIARYLAMINOTHIAZINES AS BACE1 INHIBITORS AND THEIR USE FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-11-19 | — | — | US | disclosed |
| US-4814348-A | ANTIULCER, ANTISECRETORY | ROUSSEL UCLAF (FR) | 1989-03-21 | — | — | US | disclosed |
| US-4694019-A | ANTISECRETORY, ANTIULCER AGENTS | ROUSSEL UCLAF (FR) | 1987-09-15 | — | — | US | disclosed |
| US-4536499-A | Isoxazolyl indolamines having anti-diabetic activity | SANDOZ, INC. (US) | 1985-08-20 | — | — | US | disclosed |
| US-4499279-A | ANTIDIABETIC AND HYPOGLYCEMIC AGENTS | SANDOZ, INC. (US) | 1985-02-12 | — | — | US | disclosed |
| US-4467096-A | ANTIDIABETIC AGENTS, INTERMEDIATES THEREFOR | SANDOZ, INC. (US) | 1984-08-21 | — | — | US | disclosed |
| US-4421752-A | ANTIDIABETIC AGENT | SANDOZ, INC. (US) | 1983-12-20 | — | — | US | disclosed |
| US-4419353-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1983-12-06 | — | — | US | disclosed |
| US-4397850-A | HYPOGLYCEMIC, ANTIDIABETIC | SANDOZ, INC. (US) | 1983-08-09 | — | — | US | disclosed |
| US-4336391-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |
| US-4336379-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368213-A1 | Novel Inhibitors of System Xc- | SLC7A11, SLC1A1, SLC1A2 | ALDH1A1 1920/4885L3MBTL1 2965/4885LMNA 4865/4885 |
| US-20150329506-A1 | 4,6-DIARYLAMINOTHIAZINES AS BACE1 INHIBITORS AND THEIR USE FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BACE1, APP, BACE2 | ALDH1A1 860/4885L3MBTL1 613/4885LMNA 493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.