Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | PARP2 | Q9UGN5 | 7/20 | 0.60 |
| ▸ | DHODH | Q02127 | 3/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584709 | 0.92 | AURKA (0.64) | PARP1AURKBAURKAPARP2DHODH | |
| SCHEMBL6581024 | 0.86 | AURKB (0.47) | PARP1AURKBAURKAPARP2DHODH | |
| SCHEMBL3527499 | 0.84 | AURKB (0.45) | PARP1AURKBAURKAPARP2DHODH | |
| SCHEMBL3635473 | 0.83 | AURKB (0.75) | PARP1AURKBAURKAPARP2DHODH | |
| SCHEMBL3580352 | 0.82 | AURKB (0.68) | PARP1AURKBAURKAPARP2DHODH | |
| SCHEMBL3587286 | 0.81 | AURKA (0.76) | PARP1AURKBAURKAPARP2DHODH | |
| SCHEMBL3582368 | 0.81 | AURKB (0.64) | PARP1AURKBAURKAPARP2DHODH | |
| SCHEMBL3577220 | 0.80 | AURKA (0.71) | PARP1AURKBAURKAPARP2DHODH | |
| SCHEMBL4970545 | 0.79 | PARP1 (0.73) | PARP1PARP2 | |
| SCHEMBL3582276 | 0.79 | AURKB (0.82) | PARP1AURKBAURKAPARP2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |