Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3591506 | 0.93 | KDM4E (0.53) | KDM4EHSD17B10L3MBTL1GAAALDH1A1 | |
| SCHEMBL4112789 | 0.89 | KDM4E (0.54) | KDM4EHSD17B10L3MBTL1GAAALDH1A1 | |
| SCHEMBL19601383 | 0.86 | KDM4E (0.54) | KDM4EHSD17B10L3MBTL1GAAALDH1A1 | |
| SCHEMBL20829175 | 0.85 | L3MBTL1 (0.54) | KDM4EHSD17B10L3MBTL1GAAALDH1A1 | |
| SCHEMBL4874531 | 0.84 | KDM4E (0.60) | KDM4EHSD17B10L3MBTL1GAAALDH1A1 | |
| SCHEMBL3594281 | 0.83 | CYP4F2 (0.43) | KDM4EHSD17B10ALDH1A1MAPTTDP1 | |
| SCHEMBL3227432 | 0.83 | KDM4E (0.71) | KDM4EHSD17B10L3MBTL1GAAALDH1A1 | |
| SCHEMBL29795714 | 0.82 | KDM4E (0.50) | KDM4EHSD17B10L3MBTL1GAAALDH1A1 | |
| SCHEMBL3581480 | 0.81 | KDM4E (0.54) | KDM4EHSD17B10L3MBTL1GAAALDH1A1 | |
| SCHEMBL4109638 | 0.81 | L3MBTL1 (0.57) | KDM4EHSD17B10L3MBTL1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12508268-B2 | Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy | AUCKLAND UNISERVICES LIMITED (NZ) | 2025-12-30 | — | — | US | disclosed |
| US-20240285641-A1 | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2024-08-29 | — | — | US | disclosed |
| CN-117618423-A | Inhibitors of tryptophan dioxygenase (IDO 1 and TDO) and their use in therapy | 奥克兰联合服务有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-117599049-A | Inhibitors of tryptophan dioxygenase (IDO 1 and TDO) and their use in therapy | 奥克兰联合服务有限公司 | 2024-02-27 | — | — | CN | disclosed |
| US-11826316-B2 | Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy | AUCKLAND UNISERVICES LIMITED (NZ) | 2023-11-28 | — | — | US | disclosed |
| EP-3180002-B1 | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 AND TDO) AND THEIR USE IN THERAPY | AUCKLAND UNISERVICES LTD (NZ) | 2022-04-20 | — | — | EP | disclosed |
| US-11178872-B2 | Cyclic amine compound and pest control agent | NIPPON SODA CO., LTD. (JP) | 2021-11-23 | — | — | US | disclosed |
| US-11178872-B2 | Cyclic amine compound and pest control agent | NIPPON SODA CO., LTD. (JP) | 2021-11-23 | — | — | US | disclosed |
| EP-3889137-A1 | CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT | Nippon Soda Co., Ltd. (JP) | 2021-10-06 | — | — | EP | disclosed |
| US-20210145839-A1 | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2021-05-20 | — | — | US | disclosed |
| US-20170224701-A1 | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2017-08-10 | — | — | US | disclosed |
| EP-3180002-A1 | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 AND TDO) AND THEIR USE IN THERAPY | Auckland Uniservices Limited (NZ) | 2017-06-21 | — | — | EP | disclosed |
| WO-2016024233-A1 | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 AND TDO) AND THEIR USE IN THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2016-02-18 | — | — | WO | disclosed |
| US-20100069350-A1 | New Pyridine Analogues III | ASTRAZENECA AB (SE) | 2010-03-18 | — | — | US | disclosed |
| EP-2044050-A1 | NEW PYRIDINE ANALOGUES | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| US-20080312208-A1 | Pyridine Analogues | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | US | disclosed |
| EP-1904474-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | disclosed |
| US-20080039437-A1 | New Pyridine Analogues III | ASTRAZENECA AB (SE) | 2008-02-14 | — | — | US | disclosed |
| WO-2008004946-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |
| WO-2007008140-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11826316-B2 | Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy | IDO1, TDO2, IDO2 | KDM4E 768/4885HSD17B10 1530/4885L3MBTL1 3355/4885 |
| US-20240285641-A1 | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY | IDO1, TDO2, IDO2 | KDM4E 768/4885HSD17B10 1530/4885L3MBTL1 3355/4885 |
| US-12508268-B2 | Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy | IDO1, IDO2, TDO2 | KDM4E 1473/4885HSD17B10 1489/4885L3MBTL1 3879/4885 |
| US-20080039437-A1 | New Pyridine Analogues III | P2RY12, P2RY1, P2RY11 | KDM4E 2658/4885HSD17B10 4115/4885L3MBTL1 4870/4885 |
| US-20170224701-A1 | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY | IDO1, TDO2, IDO2 | KDM4E 768/4885HSD17B10 1530/4885L3MBTL1 3355/4885 |
| US-20100069350-A1 | New Pyridine Analogues III | P2RY12, P2RY11, P2RY1 | KDM4E 3901/4885HSD17B10 3604/4885L3MBTL1 4818/4885 |
| US-20080312208-A1 | Pyridine Analogues | P2RY12, P2RY11, P2RY1 | KDM4E 1759/4885HSD17B10 3283/4885L3MBTL1 4857/4885 |
| US-20210145839-A1 | INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY | IDO1, TDO2, IDO2 | KDM4E 768/4885HSD17B10 1530/4885L3MBTL1 3355/4885 |
| US-11178872-B2 | Cyclic amine compound and pest control agent | H1-4, H1-10, NPR1 | KDM4E 587/4885HSD17B10 3853/4885L3MBTL1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.