Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 3/20 | 0.32 |
| ▸ | NSD2 | O96028 | 3/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.32 |
| ▸ | S100A4 | P26447 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | PADI1 | Q9ULC6 | 2/20 | 0.32 |
| ▸ | PADI3 | Q9ULW8 | 2/20 | 0.32 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.32 |
| ▸ | PADI2 | Q9Y2J8 | 2/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Aminopyridine SCHEMBL3603239 | 0.88 | NOS3 (0.48) | KMT2AALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL691141 | 0.86 | MEN1 (0.35) | KMT2AALDH1A1NPC1MAPTRAB9A | |
| Pyrimidine SCHEMBL3604939 | 0.80 | HTT (0.34) | NPC1MAPTRAB9AMAOB | |
| SCHEMBL3590143 | 0.74 | TSHR (0.40) | HSP90AA1KMT2AALDH1A1NPC1MAPT | |
| SCHEMBL30200273 | 0.73 | — | — | |
| SCHEMBL9806078 | 0.70 | TDP2 (0.41) | HSP90AA1KMT2AALDH1A1NPC1MAPT | |
| SCHEMBL987746 | 0.70 | TDP2 (0.41) | KMT2AALDH1A1PTPRCCTSLCTSS | |
| SCHEMBL30200347 | 0.68 | GSK3B (0.33) | KMT2AALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL30839399 | 0.66 | KDM4E (0.56) | HSP90AA1KMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL2704111 | 0.66 | KDM4E (0.56) | HSP90AA1KMT2AALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674823-B2 | DNA-PK inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2010-03-09 | — | — | US | disclosed |
| US-20070238729-A1 | DNA-PK INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-10-11 | — | — | US | disclosed |
| US-7226918-B2 | DNA-PK inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2007-06-05 | — | — | US | disclosed |
| US-20040192687-A1 | Dna-pk inhibitors | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2004-09-30 | — | — | US | disclosed |
| EP-1417196-A1 | DNA-PK INHIBITORS | Cancer Research Technology Limited (GB) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003024949-A1 | DNA-PK INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2003-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192687-A1 | Dna-pk inhibitors | ATM, CHEK1, XRCC6 | HSP90AA1 2829/4885KMT2A 854/4885ALDH1A1 3564/4885 |
| US-20070238729-A1 | DNA-PK INHIBITORS | ATM, CHEK2, CHEK1 | HSP90AA1 3755/4885KMT2A 1306/4885ALDH1A1 4037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.