Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.49 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL553506 | 1.00 | MTNR1A (0.49) | MTNR1AMTNR1BPLA2G10PLA2G2AMAOA | |
| SCHEMBL13503951 | 0.87 | MTNR1A (0.47) | MTNR1AMTNR1BPLA2G10PLA2G2AMAOA | |
| SCHEMBL2943420 | 0.86 | MTNR1A (0.47) | MTNR1AMTNR1BPLA2G10PLA2G2AMAOA | |
| SCHEMBL2943414 | 0.86 | MTNR1A (0.47) | MTNR1AMTNR1BPLA2G10PLA2G2AMAOA | |
| SCHEMBL13503680 | 0.84 | MTNR1A (0.48) | MTNR1AMTNR1BPLA2G10PLA2G2AMAOA | |
| SCHEMBL24698678 | 0.83 | ATM (0.46) | MTNR1AMTNR1BPLA2G10ALDH1A1 | |
| SCHEMBL10058366 | 0.82 | CASP1 (0.49) | — | |
| SCHEMBL2950983 | 0.82 | MTNR1A (0.51) | MTNR1AMTNR1BPLA2G10PLA2G2AMAOA | |
| SCHEMBL4901823 | 0.81 | MTNR1A (0.50) | MTNR1AMTNR1BPLA2G10PLA2G2AMAOA | |
| SCHEMBL8064065 | 0.81 | PLA2G10 (0.47) | MTNR1AMTNR1BPLA2G10PLA2G2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035879-A1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES | 2010-02-11 | — | — | US | disclosed |
| US-7585858-B2 | N-sulfonylcarboximidamide apoptosis promoters | ABBOTT LABORATORIES (US) | 2009-09-08 | — | — | US | disclosed |
| US-20050272744-A1 | N-sulfonylcarboximidamide apoptosis promoters | ABBVIE INC. | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035879-A1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | BAX, BCL2, BAD | MTNR1A 2992/4885MTNR1B 3135/4885PLA2G10 4423/4885 |
| US-20050272744-A1 | N-sulfonylcarboximidamide apoptosis promoters | BAX, BCL2, BAD | MTNR1A 2992/4885MTNR1B 3135/4885PLA2G10 4423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.