Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 14/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 14/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.54 |
| ▸ | TSHR | P16473 | 12/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12992231 | 0.87 | MAPT (0.65) | KDM4CCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL18569219 | 0.82 | CYP1A2 (0.59) | CYP1A2CYP3A4CYP2C19CYP2D6TSHR | |
| SCHEMBL31275112 | 0.81 | KDM4C (0.57) | KDM4CCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL16992915 | 0.77 | KDM4C (0.54) | KDM4CCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL24468588 | 0.76 | KDM4C (0.46) | KDM4CCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL29875781 | 0.76 | KDM4C (0.46) | KDM4CCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21639656 | 0.76 | CA1 (0.72) | KDM4CCYP1A2CYP3A4CYP2C19TSHR | |
| SCHEMBL28091678 | 0.76 | CYP1A2 (0.58) | KDM4CCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL31026830 | 0.76 | KDM4C (0.48) | KDM4CCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL29650717 | 0.76 | KDM4C (0.46) | KDM4CCYP1A2CYP3A4CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1632477-B1 | BENZAMIDE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2017-03-01 | — | — | EP | disclosed |
| US-7855198-B2 | Benzamide derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2010-12-21 | — | — | US | disclosed |
| CN-100562513-C | Benzamide derivatives or its salt | ASTELLAS PHARMA INC (JP) | 2009-11-25 | — | — | CN | disclosed |
| US-20090270365-A1 | such as N-(2,4-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide, having vanilloid receptor 1 antagonistic activity, used as analgesics | ASTELLAS PHARMA INC. (JP) | 2009-10-29 | — | — | US | disclosed |
| US-7585878-B2 | Benzamide derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2009-09-08 | — | — | US | disclosed |
| US-20070167444-A1 | Benzamide derivative or salt thereof | ASTELLAS PHARMA INC. | 2007-07-19 | — | — | US | disclosed |
| CN-1805923-A | Benzamide derivative or salt thereof | ASTELLAS PHARMA INC (JP) | 2006-07-19 | — | — | CN | disclosed |
| EP-1632477-A1 | BENZAMIDE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2006-03-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270365-A1 | such as N-(2,4-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)-2-(piperidin-1-ylmethyl)biphenyl-4-carboxamide, having vanilloid receptor 1 antagonistic activity, used as analgesics | TRPV1, TRPV2, TRPV3 | KDM4C 1364/4885CYP1A2 2476/4885CYP3A4 2822/4885 |
| US-20070167444-A1 | Benzamide derivative or salt thereof | TRPV1, BDKRB1, BDKRB2 | KDM4C 2469/4885CYP1A2 3377/4885CYP3A4 3896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.