Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 3/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | DDO | Q99489 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5529450 | 0.88 | PDE9A (0.51) | PDE9APDE1CKDM4EMAOAMAOB | |
| SCHEMBL359150 | 0.82 | KDM5A (0.57) | PDE9APDE1CKDM4EGAAALDH1A1 | |
| SCHEMBL2870927 | 0.82 | KDM5A (0.47) | PDE9AKDM4EGAAALDH1A1GLA | |
| SCHEMBL1621734 | 0.78 | PDE9A (0.62) | PDE9APDE1CKDM4EGAAALDH1A1 | |
| SCHEMBL18584332 | 0.75 | PTGES (0.49) | PDE9AKDM4EGAAPTGESALDH1A1 | |
| SCHEMBL10193365 | 0.75 | KIF11 (0.48) | PDE9APDE1CKDM4EMAOAMAOB | |
| SCHEMBL2867172 | 0.75 | ALDH1A1 (0.50) | PDE9AKDM4EALDH1A1POLBHSD17B10 | |
| SCHEMBL13280383 | 0.74 | ALDH1A1 (0.41) | PDE9AKDM4EGAAPTGESALDH1A1 | |
| SCHEMBL359483 | 0.74 | HSD11B1 (0.41) | PDE9AKDM4EGAAPTGESALDH1A1 | |
| SCHEMBL24199985 | 0.74 | PDE9A (0.58) | PDE9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2696682-A2 | MIF INHIBITORS AND THEIR USES | Innovimmune Biotherapeutics, Inc. (US) | 2014-02-19 | — | — | EP | disclosed |
| EP-2592933-A1 | MIF INHIBITORS AND THEIR USES | Gaweco, Anderson (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012142498-A2 | MIF INHIBITORS AND THEIR USES | INNOVIMMUNE BIOTHERAPEUTICS, INC. (US) | 2012-10-18 | — | — | WO | disclosed |
| WO-2012009649-A1 | MIF INHIBITORS AND THEIR USES | GAWECO ANDERSON (US) | 2012-01-19 | — | — | WO | disclosed |