Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GRM6 | O15303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10706597 | 0.85 | KMT2A (0.45) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL18884079 | 0.81 | KMT2A (0.47) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4714140 | 0.80 | MEN1 (0.40) | KMT2AMEN1KDM4EALDH1A1RECQL | |
| SCHEMBL12713446 | 0.76 | KMT2A (0.49) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL17574082 | 0.75 | KMT2A (0.45) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2919829 | 0.74 | NPC1 (0.49) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13895781 | 0.72 | KMT2A (0.51) | KMT2AMEN1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL21847322 | 0.71 | RAB9A (0.55) | KMT2AMEN1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL31200496 | 0.70 | ALDH1A1 (0.50) | KMT2AMEN1KDM4EALDH1A1THRB | |
| SCHEMBL910030 | 0.70 | ALDH1A1 (0.50) | KMT2AMEN1KDM4EALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9657031-B2 | Ant-ligands molecules and biological applications | UNIVERSITE DE VERSAILLES-SAINT-QUENTIN-EN-YVELINES (FR) | 2017-05-23 | — | — | US | disclosed |
| US-20140350033-A1 | ANT-LIGANDS MOLECULES AND BIOLOGICAL APPLICATIONS | MITOLOGICS (FR) | 2014-11-27 | — | — | US | disclosed |
| US-8288395-B2 | Pyrimido-benzimidzole derivatives and the use thereof in the form of agonists or antagonists of melanocortin receptors | IPSEN PHARMA S.A.S. (FR) | 2012-10-16 | — | — | US | disclosed |
| CN-1968955-B | Pyrimido-benzimidazole derivatives and their use as melanocortin receptor agonists or antagonists | IPSEN PHARMA SAS | 2012-06-13 | — | — | CN | disclosed |
| US-20100256135-A1 | PYRIMIDO-BENZIMIDZOLE DERIVATIVES AND THE USE THEREOF IN THE FORM OF AGONISTS OR ANTAGONISTS OF MELANOCORTIN RECEPTORS | IPSEN PHARMA S.A.S. (FR) | 2010-10-07 | — | — | US | disclosed |
| US-7763725-B2 | used for treating metabolic, nervous sytsem and skin disorders,inflammatory diseases, obesity, cachexia, erectile dysfunction, neuropathic pain, or as antidepressants, anxiolytic and anticarcinogenic agents | IPSEN PHARMA S.A.S. (FR) | 2010-07-27 | — | — | US | disclosed |
| US-20090209531-A1 | Pyrimido-Benzimidazole Derivatives and the Use Thereof in the Form of Agonists and Antagonists of Melanocortin Receptors | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S. (FR) | 2009-08-20 | — | — | US | disclosed |
| CN-1968955-A | Pyrimido-benzimidazole derivatives and their use as melanocortin receptor agonists or antagonists | SOD CONSEILS RECH APPLIC (FR) | 2007-05-23 | — | — | CN | disclosed |
| US-6441169-B1 | PHENYL, THIENYL (INCLUDING ALL 3 ISOMERS), THIAZOLYL OR PYRIDYL PYRIMIDINES; PROTECTING PLANTS AGAINST DISEASES CAUSED BY FUNGI, BACTERIA OR VIRUSES | SYNGENTA CROP PROTECTION, INC. | 2002-08-27 | — | — | US | disclosed |
| EP-0888359-B1 | PYRIMIDIN-4-ONE DERIVATIVES AS PESTICIDE | SYNGENTA PARTICIPATIONS AG (CH) | 2002-05-02 | — | — | EP | disclosed |
| US-6262058-B1 | Pyrimidin-4-one derivatives as pesticide | SYNGENTA CROP PROTECTION, INC. | 2001-07-17 | — | — | US | disclosed |
| EP-1015435-A1 | PYRIMIDIN-2-OXY-4-ONE AND PYRIMIDIN-2-OXY-4-THIONE DERIVATIVES | Novartis AG (CH) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999011631-A1 | PYRIMIDIN-2-OXY-4-ONE AND PYRIMIDIN-2-OXY-4-THIONE DERIVATIVES | NOVARTIS AG (CH) | 1999-03-11 | — | — | WO | disclosed |
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| EP-0888359-A1 | PYRIMIDIN-4-ONE DERIVATIVES AS PESTICIDE | Novartis AG (CH) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997033890-A1 | PYRIMIDIN-4-ONE DERIVATIVES AS PESTICIDE | NOVARTIS AG (CH) | 1997-09-18 | — | — | WO | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140350033-A1 | ANT-LIGANDS MOLECULES AND BIOLOGICAL APPLICATIONS | CXCR3, ACKR3, CCR3 | KMT2A 4672/4885MEN1 2079/4885SMN1; SMN2 4745/4885 |
| US-20100256135-A1 | PYRIMIDO-BENZIMIDZOLE DERIVATIVES AND THE USE THEREOF IN THE FORM OF AGONISTS OR ANTAGONISTS OF MELANOCORTIN RECEPTORS | MC4R, MC5R, MC1R | KMT2A 2410/4885MEN1 1090/4885SMN1; SMN2 3807/4885 |
| US-20090209531-A1 | Pyrimido-Benzimidazole Derivatives and the Use Thereof in the Form of Agonists and Antagonists of Melanocortin Receptors | MC4R, MC5R, MC1R | KMT2A 2207/4885MEN1 856/4885SMN1; SMN2 3545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.