Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 8/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3594920 | 0.91 | PTGER1 (0.41) | ICMTPTGER1IRAK4XDHPDE4B | |
| SCHEMBL3595139 | 0.91 | PTGER1 (0.41) | ICMTPTGER1XDHPDE4BTBXA2R | |
| SCHEMBL3596646 | 0.86 | ALDH1A1 (0.44) | PTGER1ALDH1A1KDM4E | |
| SCHEMBL3589491 | 0.82 | NPC1 (0.44) | PTGER1IRAK4ALDH1A1XDHKDM4E | |
| SCHEMBL3587219 | 0.81 | ALDH1A1 (0.44) | ALDH1A1XDHKDM4E | |
| SCHEMBL4354618 | 0.81 | KDM4E (0.36) | PTGER1ALDH1A1KDM4EPDE4B | |
| SCHEMBL3603195 | 0.80 | CNR2 (0.42) | — | |
| SCHEMBL3599804 | 0.80 | HDAC1 (0.40) | PTGER1IRAK4XDH | |
| SCHEMBL4037157 | 0.79 | ICMT (0.41) | ICMTPTGER1IRAK4PDE4B | |
| SCHEMBL4350902 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004240-A1 | Indole Compounds | GLAXO GROUP LIMITED (GB) | 2010-01-07 | — | — | US | disclosed |
| US-20100004240-A1 | Indole Compounds | GLAXO GROUP LIMITED (GB) | 2010-01-07 | — | — | US | disclosed |
| US-20100004240-A1 | Indole Compounds | GLAXO GROUP LIMITED (GB) | 2010-01-07 | — | — | US | disclosed |
| WO-2008006795-A2 | INDOLE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004240-A1 | Indole Compounds | IDO1, TPH1, IDO2 | ICMT 441/4885PTGER1 229/4885IRAK4 3924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.