Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.94 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL3593172 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL2784551 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL20994738 | 0.94 | — | — | |
| Malic Acid SCHEMBL162118 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL1093517 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL118155 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815132 | 0.94 | CA4 (1.00) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL21815634 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL674137 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL18393648 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390511-B2 | Compositions containing vitamin E and saw palmetto | PROETHIC PHARMACEUTICALS, INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-20080090297-A1 | Methods for determining the metal bioavailability of metal sources | NOVUS INTERNATIONAL INC. (US) | 2008-04-17 | — | — | US | disclosed |
| US-20070172528-A1 | Compositions containing vitamin E and saw palmetto | PROETHIC PHARMACEUTICALS, INC. (US) | 2007-07-26 | — | — | US | disclosed |
| US-7186421-B2 | Mineral additives for improved processing of compositions containing vitamin E and saw palmetto | PROETHIC PHARMACEUTICALS, INC. (US) | 2007-03-06 | — | — | US | disclosed |
| WO-2007001506-A1 | COMPOSITION AND METHOD OF PROTECTION AGAINST UV IRRADIATION | PURE LABORATORIES, LLC (US) | 2007-01-04 | — | — | WO | disclosed |
| US-20060292094-A1 | Composition and method of protection against UV irradiation | PURE LABORATORIES, LLC | 2006-12-28 | — | — | US | disclosed |
| US-20060068038-A1 | Mineral additives for improved processing of compositions containing vitamin E and saw palmetto | PROETHIC LABORATORIES, L.L.C. (US) | 2006-03-30 | — | — | US | disclosed |
| US-20060068037-A1 | Admixing process for making compositions containing vitamin E and saw palmetto | PROETHIC LABORATORIES, L.L.C. (US) | 2006-03-30 | — | — | US | disclosed |
| US-20050191369-A1 | Compositions comprising vitamin E and saw palmetto | PROETHIC LABORATORIES, L.L.C. (US) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050191369-A1 | Compositions comprising vitamin E and saw palmetto | TTPA, GPX4, CYP24A1 | CA4 4393/4885CTSL 1440/4885CA2 4777/4885 |
| US-20070172528-A1 | Compositions containing vitamin E and saw palmetto | TTPA, CYP24A1, SOST | CA4 4403/4885CTSL 1066/4885CA2 4413/4885 |
| US-20060068037-A1 | Admixing process for making compositions containing vitamin E and saw palmetto | TTPA, GPX4, PNPO | CA4 4297/4885CTSL 1845/4885CA2 4799/4885 |
| US-20060068038-A1 | Mineral additives for improved processing of compositions containing vitamin E and saw palmetto | SOST, TTPA, CYP24A1 | CA4 3751/4885CTSL 677/4885CA2 3830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.