Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.44 |
| ▸ | EED | O75530 | 1/20 | 0.43 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.43 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.43 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.43 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29267085 | 0.81 | PARP1 (0.39) | PARP1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL28614035 | 0.81 | PARP1 (0.52) | PARP1ALDH1A1GPR119 | |
| SCHEMBL358681 | 0.80 | EED (0.46) | PARP1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL20135591 | 0.79 | GPR119 (0.50) | IRAK4GPR119DDB1CRBNPTPN2 | |
| SCHEMBL2270749 | 0.79 | CCNT1 (0.41) | PARP1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL20606506 | 0.78 | IRAK4 (0.46) | IRAK4EEDRBBP4SUZ12EZH2 | |
| SCHEMBL358920 | 0.78 | NR3C1 (0.43) | PARP1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL25104075 | 0.78 | NR1H2 (0.41) | IRAK4EEDRBBP4SUZ12EZH2 | |
| SCHEMBL30158059 | 0.78 | MAPT (0.44) | IRAK4ALDH1A1GPR119DDB1CRBN | |
| SCHEMBL28624126 | 0.77 | PARP1 (0.55) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |