Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 3/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 5/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.42 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.42 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.42 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL358681 | 0.90 | EED (0.46) | NR3C1PARP1EEDRBBP4SUZ12 | |
| SCHEMBL359239 | 0.89 | PARP1 (0.51) | NR3C1BACE1PARP1GPR119 | |
| SCHEMBL359388 | 0.83 | PARP1 (0.50) | PARP1 | |
| SCHEMBL358670 | 0.80 | PARP1 (0.52) | NR3C1PARP1GPR119 | |
| SCHEMBL359451 | 0.78 | PARP1 (0.51) | PARP1FPR2 | |
| SCHEMBL359420 | 0.78 | PARP1 (0.45) | BACE1PARP1EEDRBBP4SUZ12 | |
| SCHEMBL368905 | 0.77 | PARP1 (0.49) | NR3C1PARP1GPR119 | |
| SCHEMBL359223 | 0.76 | PARP1 (0.49) | PARP1GPR119 | |
| SCHEMBL358653 | 0.76 | PARP1 (0.47) | NR3C1PARP1GPR119STS | |
| SCHEMBL30175636 | 0.74 | LMNA (0.44) | PARP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |