Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320347 | 0.82 | ADRB1 (0.63) | KDM4ENPC1RAB9AHTR3ASMN1; SMN2 | |
| SCHEMBL3587877 | 0.80 | HTR3A (0.50) | KDM4ENPC1RAB9AHTR3ASMN1; SMN2 | |
| SCHEMBL30191093 | 0.78 | GAA (0.69) | KDM4ENPC1RAB9AHTR3ASMN1; SMN2 | |
| SCHEMBL6151809 | 0.78 | GAA (0.69) | KDM4ENPC1RAB9AHTR3ASMN1; SMN2 | |
| SCHEMBL6150891 | 0.78 | GAA (0.69) | KDM4ENPC1RAB9AHTR3ASMN1; SMN2 | |
| SCHEMBL519972 | 0.78 | GAA (0.69) | KDM4ENPC1RAB9AHTR3ASMN1; SMN2 | |
| SCHEMBL14922269 | 0.78 | KMT2A (0.53) | KDM4ENPC1RAB9AHTR3ASMN1; SMN2 | |
| SCHEMBL23316271 | 0.77 | KDM4E (0.47) | KDM4ENPC1RAB9AHTR3ASMN1; SMN2 | |
| SCHEMBL8318825 | 0.76 | MAPT (0.59) | KDM4ENPC1RAB9AHTR3ASMN1; SMN2 | |
| SCHEMBL1911838 | 0.75 | SIRT6 (0.56) | KDM4ENPC1RAB9AHTR3ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029636-A1 | Lck inhibitors | NOVARTIS AG (CH) | 2010-02-04 | — | — | US | disclosed |
| CN-101516888-A | Pyrazolo [1, 5-a] pyrimidine derivatives and their therapeutic use | NOVARTIS AG (CH) | 2009-08-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029636-A1 | Lck inhibitors | LCK, ZAP70, FYN | KDM4E 557/4885NPC1 3655/4885RAB9A 2814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.