Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | ALAD | P13716 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4952543 | 0.81 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL6623848 | 0.81 | BCAT2 (0.55) | ALDH1A1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL4948064 | 0.77 | PTGS1 (0.50) | ALDH1A1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL4951370 | 0.77 | PTGS1 (0.55) | ALDH1A1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL4950510 | 0.77 | ERN1 (0.47) | ALDH1A1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL4950473 | 0.75 | MEN1 (0.43) | ALDH1A1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL1791803 | 0.74 | — | — | |
| SCHEMBL4951480 | 0.73 | MEN1 (0.45) | ALDH1A1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL4952432 | 0.73 | ADRB2 (0.48) | ALDH1A1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL4948515 | 0.73 | PTGS1 (0.57) | ALDH1A1MEN1KMT2AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652064-B2 | AMPA receptor potentiators | ELI LILLY AND COMPANY (US) | 2010-01-26 | — | — | US | disclosed |
| EP-1893597-B1 | AMPA RECEPTOR POTENTIATORS | LILLY CO ELI (US) | 2008-11-12 | — | — | EP | disclosed |
| US-7393868-B2 | AMPA receptor potentiators | ELI LILLY AND COMPANY (US) | 2008-07-01 | — | — | US | disclosed |
| EP-1893597-A2 | AMPA RECEPTOR POTENTIATORS | ELI LILLY AND COMPANY (US) | 2008-03-05 | — | — | EP | disclosed |
| US-20070142441-A1 | AMPA receptor potentiators | ELI LILLY AND COMPANY | 2007-06-21 | — | — | US | disclosed |
| WO-2006132811-A2 | AMPA RECEPTOR POTENTIATORS | ELI LILLY AND COMPANY (US) | 2006-12-14 | — | — | WO | disclosed |
| US-20060276532-A1 | AMPA RECEPTOR POTENTIATORS | ELI LILLY AND COMPANY | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142441-A1 | AMPA receptor potentiators | GABRE, GRIN1, GRIK2 | ALDH1A1 928/4885MEN1 4077/4885KMT2A 2393/4885 |
| US-20060276532-A1 | AMPA RECEPTOR POTENTIATORS | GABRE, GRIN1, GRIK2 | ALDH1A1 928/4885MEN1 4077/4885KMT2A 2393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.