Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28393820 | 0.72 | CA1 (0.47) | ALDH1A1HSD17B10KDM4EALOX15CASP1 | |
| SCHEMBL20888747 | 0.71 | HDAC1 (0.40) | HDAC1ALDH1A1HSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL8058129 | 0.71 | ALDH1A1 (0.44) | ALDH1A1HSD17B10KDM4EALOX15CASP1 | |
| SCHEMBL21651799 | 0.71 | MEN1 (0.53) | ALDH1A1HSD17B10ALOX15CASP3SMN1; SMN2 | |
| SCHEMBL21606296 | 0.70 | ALOX15 (0.58) | HDAC1ALDH1A1HSD17B10KDM4EALOX15 | |
| SCHEMBL20571535 | 0.70 | ALDH1A1 (0.56) | ALDH1A1HSD17B10KDM4EALOX15CASP1 | |
| SCHEMBL12927456 | 0.69 | ALDH1A1 (0.46) | ALDH1A1HSD17B10KDM4EALOX15CASP1 | |
| SCHEMBL21932308 | 0.69 | LMNA (0.45) | ALDH1A1HSD17B10ALOX15CASP3SMN1; SMN2 | |
| SCHEMBL21932485 | 0.69 | LMNA (0.45) | ALDH1A1HSD17B10ALOX15CASP3SMN1; SMN2 | |
| SCHEMBL21932259 | 0.69 | LMNA (0.45) | ALDH1A1HSD17B10ALOX15CASP3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298314-A1 | NOVEL JNK INHIBITORS | SCHERING CORPORATION | 2010-11-25 | — | — | US | disclosed |
| EP-2134713-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008082490-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298314-A1 | NOVEL JNK INHIBITORS | MAPK1, MAPKAPK2, MAP4K2 | HDAC1 362/4885ALDH1A1 1430/4885HSD17B10 3024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.