Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 5/20 | 0.46 |
| ▸ | TDO2 | P48775 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL127629 | 0.84 | IDO1 (0.46) | HTR2ASLC6A4SLC6A2SLC6A3CHRM2 | |
| SCHEMBL1773224 | 0.82 | SLC6A4 (0.54) | HTR2ASLC6A4SLC6A2SLC6A3CHRM2 | |
| Water SCHEMBL11878861 | 0.82 | IDO1 (0.44) | HTR2ASLC6A4SLC6A2SLC6A3CHRM2 | |
| Methane SCHEMBL29089947 | 0.82 | IDO1 (0.44) | HTR2ASLC6A4SLC6A2SLC6A3CHRM2 | |
| Ammonia Solution, Strong SCHEMBL7282272 | 0.82 | IDO1 (0.44) | HTR2ASLC6A4SLC6A2SLC6A3CHRM2 | |
| SCHEMBL73865 | 0.80 | IDO1 (0.70) | SLC6A4SLC6A2SLC6A3CHRM2HTR1A | |
| SCHEMBL434700 | 0.78 | CHRNB2 (0.52) | HTR2ASLC6A4SLC6A2SLC6A3IDO1 | |
| SCHEMBL3692372 | 0.77 | HTR2A (0.60) | HTR2ASLC6A4SLC6A2SLC6A3CHRM2 | |
| SCHEMBL13865458 | 0.77 | HTR2A (0.60) | HTR2ASLC6A4SLC6A2SLC6A3CHRM2 | |
| SCHEMBL10981079 | 0.76 | IDO1 (0.67) | IDO1TDO2ALDH1A1TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842822-B2 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY (US) | 2010-11-30 | — | — | US | disclosed |
| US-20090298925-A1 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | DURST GREGORY LEE | 2009-12-03 | — | — | US | disclosed |
| US-7585985-B2 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY (US) | 2009-09-08 | — | — | US | disclosed |
| US-20080312312-A1 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | DURST GREGORY LEE | 2008-12-18 | — | — | US | disclosed |
| US-7442812-B2 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY (US) | 2008-10-28 | — | — | US | disclosed |
| US-7419967-B2 | Sulfonamide inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-02 | — | — | US | disclosed |
| EP-1626974-B1 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | LILLY CO ELI (US) | 2008-08-27 | — | — | EP | disclosed |
| US-20070106082-A1 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| US-20060172936-A1 | Sulfonamide inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED | 2006-08-03 | — | — | US | disclosed |
| EP-1626974-A2 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2006-02-22 | — | — | EP | disclosed |
| EP-1086076-B1 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMA (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2004094400-A2 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2004-11-04 | — | — | WO | disclosed |
| US-20040097594-A1 | Sulfonamide inhibitors of aspartyl protease | HALE MICHAEL ROBIN (US) | 2004-05-20 | — | — | US | disclosed |
| US-6613743-B2 | Administering to a patient suffering from viral infections a sulfonamides antiviral agents which are aspartyl protease inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2003-09-02 | — | — | US | disclosed |
| US-20020049201-A1 | Sulfonamide inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED | 2002-04-25 | — | — | US | disclosed |
| EP-1086076-A1 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | Vertex Pharmaceuticals Incorporated (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999065870-A2 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-12-23 | — | — | WO | disclosed |
| US-4098816-A | HYPOGLYCEMIC AGENTS AND ANTILIPEMIC AGENTS | BEECHAM GROUP LIMITED (GB) | 1978-07-04 | — | — | US | disclosed |
| US-4035426-A | Diarylcyclobutanes | MEAD JOHNSON & COMPANY (US) | 1977-07-12 | — | — | US | disclosed |
| US-3939196-A | Diarylcyclobutanes | MEAD JOHNSON & COMPANY (US) | 1976-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097594-A1 | Sulfonamide inhibitors of aspartyl protease | SPINT2, PRSS1, DNPEP | HTR2A 3674/4885SLC6A4 2746/4885SLC6A2 3134/4885 |
| US-20060172936-A1 | Sulfonamide inhibitors of aspartyl protease | SPINT2, PRSS1, DNPEP | HTR2A 3674/4885SLC6A4 2746/4885SLC6A2 3134/4885 |
| US-20070106082-A1 | Substituted benzopyrans as selective estrogen receptor-beta agonists | MCHR1, MCHR2, MC1R | HTR2A 177/4885SLC6A4 1279/4885SLC6A2 842/4885 |
| US-20020049201-A1 | Sulfonamide inhibitors of aspartyl protease | SPINT2, PRSS1, DNPEP | HTR2A 3674/4885SLC6A4 2746/4885SLC6A2 3134/4885 |
| US-20090298925-A1 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | GPER1, ESR2, ESR1 | HTR2A 308/4885SLC6A4 1051/4885SLC6A2 1226/4885 |
| US-20080312312-A1 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | GPER1, ESR2, ESR1 | HTR2A 308/4885SLC6A4 1051/4885SLC6A2 1226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.