SCHEMBL359895

SCHEMBL359895

Sc1ccc2ncccc2c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.63
POLB P06746 2/20 0.63
RAB9A P51151 2/20 0.63
ALDH1A1 P00352 6/20 0.59
MAPT P10636 5/20 0.59
HTT P42858 4/20 0.59
KDM4E B2RXH2 3/20 0.59
ATM Q13315 2/20 0.59
CASP1 P29466 2/20 0.59
TP53 P04637 1/20 0.59
HSP90AA1 P07900 1/20 0.59
HSP90AB1 P08238 1/20 0.59
TSHR P16473 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
HSD17B10 Q99714 1/20 0.59
DYRK1A Q13627 1/20 0.50
MEN1 O00255 4/20 0.49
KMT2A Q03164 4/20 0.49
CASP3 P42574 1/20 0.47
SENP7 Q9BQF6 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9429245 0.83 ALDH1A1 (0.59) NPC1POLBRAB9AALDH1A1MAPT
SCHEMBL21507918 0.80 NPC1 (0.65) NPC1POLBRAB9AALDH1A1MAPT
SCHEMBL2010960 0.78 NPC1 (0.63) NPC1POLBRAB9AALDH1A1MAPT
SCHEMBL1818445 0.77 CYP3A4 (0.59) NPC1POLBRAB9AALDH1A1MAPT
SCHEMBL29757180 0.77 NPC1 (1.00) NPC1POLBRAB9AALDH1A1MAPT
SCHEMBL30743 0.77 NPC1 (1.00) NPC1POLBRAB9AALDH1A1MAPT
SCHEMBL3284522 0.77 MAPT (0.61) NPC1POLBRAB9AALDH1A1MAPT
SCHEMBL29350099 0.76 NPC1 (0.65) NPC1POLBRAB9AALDH1A1MAPT
SCHEMBL150476 0.76 NPC1 (0.65) NPC1POLBRAB9AALDH1A1MAPT
SCHEMBL3694131 0.76 NPC1 (0.65) NPC1POLBRAB9AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4241800-B1 ABSORBABLE IMPLANTABLE MEDICAL DEVICE MADE OF IRON-BASED ALLOY BIOTYX MEDICAL SHENZHEN CO LTD (CN) 2025-08-27 EP claimed
EP-3400969-B1 IMPLANTED DEVICE BIOTYX MEDICAL SHENZHEN CO LTD (CN) 2021-05-19 EP claimed
EP-1351979-B1 REGULATED ACTIVATION OF CELL-MEMBRANE RECEPTORS BY METAL-CHELATING AGONISTS SMITHKLINE BEECHAM CORP (US) 2008-01-16 EP claimed
EP-0906947-B1 Indolocarbazole electroluminescent devices XEROX CORP (US) 2003-05-21 EP claimed
EP-0661324-B1 Hight-initiated cationic curable epoxyresin compositions and their use DELO INDUSTRIEKLEBSTOFFE GMBH (DE) 2000-07-12 EP claimed
EP-0661324-A1 Hight-initiated cationic curable epoxyresin compositions and their use THERA Patent GmbH & Co. KG Gesellschaft für industrielle Schutzrechte (DE) 1995-07-05 EP claimed
US-4036834-A ANTIBACTERIAL YAMANOUCHI PHARMACEUTICAL CO., LTD. (JA) 1977-07-19 US claimed
US-20250223291-A1 IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS INCYTE CORPORATION 2025-07-10 US disclosed
US-12084449-B2 Imidazotriazines and imidazopyrimidines as kinase inhibitors INCYTE HOLDINGS CORPORATION (US) 2024-09-10 US disclosed
US-20240067664-A1 Organic Compound, Light-Emitting Device, Display Device, Electronic Device, Light-Emitting Apparatus, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2024-02-29 US disclosed
US-20230002392-A1 Imidazotriazines and Imidazopyrimidines as Kinase Inhibitors INCYTE CORPORATION 2023-01-05 US disclosed
US-11261191-B2 Imidazotriaines and imidazopyrimidines as kinase inhibitors INCYTE HOLDINGS CORPORATION (US) 2022-03-01 US disclosed
EP-3290525-B1 METHOD FOR SCREENING DRUG AND THERAPEUTIC TARGET USED FOR TREATING ALZHEIMER'S DISEASE JIANGSU NUO BETA PHARMACEUTICAL TECH CO LTD (CN) 2022-02-23 EP disclosed
WO-1998023581-A1 BENZAMIDOALDEHYDES AND THEIR USE AS CYSTEINE PROTEASE INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1998-06-04 WO disclosed
EP-0688804-A2 Cationically hardening multicomponent epoxy resin compositions and a process for their cure THERA Patent GmbH & Co. KG Gesellschaft für industrielle Schutzrechte (DE) 1995-12-27 EP disclosed
EP-0661324-A1 Hight-initiated cationic curable epoxyresin compositions and their use THERA Patent GmbH & Co. KG Gesellschaft für industrielle Schutzrechte (DE) 1995-07-05 EP disclosed
EP-0048834-B1 METHOD FOR MEASUREMENT OF TRACE ENZYMES FUJI PHOTO FILM CO., LTD. (JP) 1985-06-19 EP disclosed
US-4414325-A PHOTOGRAPHY FUJI PHOTO FILM CO., LTD. (JP) 1983-11-08 US disclosed
EP-0048834-A1 Method for measurement of trace enzymes FUJI PHOTO FILM CO., LTD. (JP) 1982-04-07 EP disclosed
US-3956345-A POLYESTER CIBA-GEIGY AG (CH) 1976-05-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230002392-A1 Imidazotriazines and Imidazopyrimidines as Kinase Inhibitors ERBB2, MERTK, ABL1 NPC1 3650/4885POLB 3413/4885RAB9A 3414/4885
US-20250223291-A1 IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS ERBB2, MERTK, ABL1 NPC1 3650/4885POLB 3413/4885RAB9A 3414/4885
US-12084449-B2 Imidazotriazines and imidazopyrimidines as kinase inhibitors ERBB2, MERTK, ABL1 NPC1 3650/4885POLB 3413/4885RAB9A 3414/4885
US-11261191-B2 Imidazotriaines and imidazopyrimidines as kinase inhibitors MET, RET, ERBB2 NPC1 3792/4885POLB 3147/4885RAB9A 2986/4885
US-20240067664-A1 Organic Compound, Light-Emitting Device, Display Device, Electronic Device, Light-Emitting Apparatus, and Lighting Device CCND1, CCND2, DRD1 NPC1 4220/4885POLB 2617/4885RAB9A 2153/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.