Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 17/20 | 0.65 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23586414 | 0.85 | ROCK2 (0.66) | ROCK2ROCK1 | |
| SCHEMBL18741188 | 0.85 | ROCK2 (0.61) | ROCK2ROCK1 | |
| SCHEMBL18741190 | 0.85 | LMNA (0.56) | ROCK2ROCK1 | |
| SCHEMBL4879445 | 0.84 | ROCK2 (0.60) | ROCK2ROCK1 | |
| SCHEMBL4879066 | 0.82 | ROCK2 (0.68) | ROCK2ROCK1 | |
| SCHEMBL18741205 | 0.82 | ROCK2 (0.51) | ROCK2ROCK1 | |
| SCHEMBL9416647 | 0.81 | ROCK2 (0.65) | ROCK2ROCK1SRC | |
| SCHEMBL15968109 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL5724150 | 0.79 | ROCK2 (0.68) | ROCK2ROCK1SRC | |
| SCHEMBL4883200 | 0.78 | MAOB (0.62) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593107-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009194-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |