Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.68 |
| ▸ | MLYCD | O95822 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4882259 | 0.87 | MLYCD (0.59) | ROCK2ROCK1MLYCDMEN1KMT2A | |
| SCHEMBL4882240 | 0.84 | MAPK14 (0.59) | ROCK2ROCK1MLYCDMAPK14HDAC3 | |
| SCHEMBL23447721 | 0.83 | MLYCD (0.77) | MLYCDMEN1KMT2APLA2G1BCYP1A2 | |
| SCHEMBL5227678 | 0.83 | MLYCD (0.86) | ROCK2MLYCDMEN1KMT2APLA2G1B | |
| SCHEMBL15967739 | 0.82 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL360181 | 0.82 | ROCK2 (0.65) | ROCK2ROCK1 | |
| SCHEMBL5261051 | 0.81 | MLYCD (0.80) | MLYCDMEN1KMT2APLA2G1BCYP1A2 | |
| SCHEMBL18741190 | 0.81 | LMNA (0.56) | ROCK2ROCK1LMNAHPGD | |
| SCHEMBL23586414 | 0.81 | ROCK2 (0.66) | ROCK2ROCK1HDAC3HDAC1HDAC2 | |
| SCHEMBL1568282 | 0.81 | MLYCD (0.74) | ROCK2ROCK1MLYCDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | ICAGEN, INC. (US) | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | SCN3A, TRPV3, HCN3 | ROCK2 4342/4885ROCK1 4527/4885MLYCD 3862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.